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Flutamide Raw Materials powder Flutamide
Product Overview:
Flutamide is a non-steroidal androgen antagonist belonging to the acylaniline group and is a first-line treatment for prostate cancer. It was first designed and synthesized by Schering-Ploug h Company in the United States, and was first marketed in the United States in 1989 as a treatment for prostate cancer. Because flutamide itself does not have any hormonal activity, the treatment of prostate disease effect is good, and has no effect on cardiovascular, and can maintain the patient's sexual function, at present in Europe and the United States has gradually become a common drug for the treatment of prostate cancer and prostate hyperplasia, but also can be used for androgen-related non-prostate diseases, there have been a large number of international studies. Moreover, flutamide has a low incidence of adverse reactions and can be well tolerated by patients when taken orally at low doses for multiple times, so it is widely used.
Flutamide Raw Materials powder Flutamide Attributes
CAS:13311-84-7
MF:C11H11F3N2O3
MW:276.21
EINECS:236-341-9
Specification: 99% min Flutamide powder
Sample:Flutamide powder
Packaging:1kg/bag, 25kg/drum
From:Henrikang
Appearance:light yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Flutamide Raw Materials powder Flutamide Details
1. Anti-androgen
Flutamide has an anti-androgen effect by blocking androgen receptors and reducing testosterone levels in the body.
2. Inhibit estrogen synthesis
The drug can interfere with multiple links in the cholesterol metabolism process, reduce the liver's ability to synthesize estrogen, and indirectly play a role in inhibiting estrogen.
3. Improve prostate cancer symptoms
Flutamide can reduce the stimulation of androgens on prostate cells and reduce the symptoms of frequent urination and urgent urination caused by prostate cancer.
4. Alleviate prostate cancer progression
The drug has an anti-tumor effect that can slow the growth of prostate cancer cells and prevent further deterioration of the disease.
5. Improve your quality of life
After the use of flutamide, the patient's condition is controlled or alleviated, the related discomfort can be reduced or eliminated, and the quality of life and mobility can be improved.
Uses of Flutamide powder.
Non-steroidal androgen antagonists inhibit the conversion of testosterone into dihydrotestosterone and can block the binding of dihydrotestosterone to intracellular receptors in the prostate at the cellular level, thus inhibiting the growth stimulating effect of androgens on the prostate. It is effective orally. For the treatment of prostate cancer and prostatic megaly and luteinizing and releasing hormone - Lianpu, can treat advanced prostate cancer, prostatic megaly. Anticancer and antiandrogen drugs. It is used to treat advanced prostate cancer and prostatic hypertrophy that cannot be treated with surgery or radiation.
Pharmacological action of Flutamide powder.
Flutamide competes with androgens for androgen receptors at tumor sites, blocks uptake of androgens by cells, and inhibits the binding of androgens to target organs. After binding with androgen receptor, the product forms a receptor complex, enters the nucleus, and binds to nuclear protein, thus inhibiting the growth of tumor cells.
Product Method of Bulk Flutamide powder.
Trifluoromethyl benzene was nitrated to produce m-nitrotrifluoromethyl benzene, reduced to m-trifluoromethyl aniline, and reacted with isobutyryl chloride, and then nitrated to produce flutamide.
Or by the acylation of 3-trifluoromethyl - 4-nitroaniline and isobutyryl chloride.
