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  • Antitumor agent Carboplatin raw material Powder

    • Antitumor agent Carboplatin raw material Powder
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    Product Overview:

    Carboplatin is a second-generation platinum anti-tumor drug with similar anti-cancer activity to cisplatin, but nephrotoxicity, ototoxicity, neurotoxicity, especially gastrointestinal reactions, are significantly lower than cisplatin, and the anti-tumor spectrum is not as broad as cisplatin. Its mechanism of action is mainly to cause cross-linking between and within DNA strands, interfere with DNA molecules, inhibit cellular DNA synthesis, and mainly act on the N-7 and O-6 atoms of guanine in DNA, resulting in cytotoxic effects

    Antitumor agent Carboplatin raw material Powder Attributes

    Carboplatin Raw Materials Powder

    CAS:41575-94-4

    MF:C6H12N2O4Pt

    Carboplatin

    MW:371.25

    EINECS:255-446-0

    Specification: 99% min Carboplatin Powder

    Sample:Carboplatin Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:white

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Antitumor agent Carboplatin raw material Powder Details

    Carboplatin powder Usage and Synthesis.

    Carboplatin is a platinum-based anticancer drug that damages DNA by forming in-chain conjugations with neighboring guanine residues. The anti-tumor effect of these drugs is achieved through the activity of DNA mismatch repair loss (MMR vaccine) and induced programmed cell death.

    The role and use of the second generation of platinum anticancer drugs are basically the same as that of cisplatin. It is more active than cisplatin for some tumors and stronger than cisplatin as a radiosensitizer under hypoxia conditions. It is mainly used for ovarian cancer, testicular cancer, small cell lung cancer and head and neck cancer.

    Carboplatin Powder

    Uses of Carboplatin.

    The range of action of carboplatin is generally similar to cisplatin. The main advantage of this new analogue is its difference in toxicity. Carboplatin is currently used as palliative care for recurrent ovarian cancer, including in patients who have previously received cisplatin. Clinical studies have also shown that carboplatin can produce an objective response to head and neck tumors, small cell lung cancer, and spermatogonia of the testis. At present, carbatin is mainly used in the treatment of small cell lung cancer, ovarian cancer, testicular cancer, germ cell tumor, thyroid cancer, nasopharyngeal cancer, and can also be used in cervical cancer, non-small cell lung cancer, esophageal cancer, seminoma, bladder cancer, mesothelioma, pediatric brain tumor and other head and neck cancer and other malignant tumors. It can be used in patients who cannot tolerate cisplatin due to renal impairment, refractory vomiting, hearing loss, or neurotoxicity. No cross-resistance with other chemotherapy drugs, can be used alone, can also be used with other chemical drugs, and can be combined with surgery, radiotherapy to improve the efficacy.

    Carboplatin

    In vitro study of Carboplatin.

    Product Methods of Carboplatin.

    Potassium chloroplatinate reacts with hydrazine hydrochloride and potassium iodide to obtain cisiodoamine platin, which can be purified by recrystallization of a mixture of dimethylformamide and ethanol. Cisiodoplatine was added to the water, silver sulfate was slowly added, and the reaction was 2 ~ 3h at 20 ~ 25℃. Filter the insoluble matter, slowly add barium 1, 1-cyclobutane dicarboxylate (obtained from the reaction of 1, 1-cyclobutane dicarboxylate and barium hydroxide) to the filtrate, react at room temperature for 3 ~ 4h, stand for more than 12h, filter, and steam the filtrate. The resulting solids were washed with water and 95% ethanol, respectively. Drying at about 60℃, carboplatin is obtained. The yield is 87.5%.

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