Exemestane Powder Raw Material

Product Name: Exemestane Powder Raw Material

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Specification​: 99% min Exemestane Powder

Test Method: HPLC

CAS: 107868-30-4

MF: C20H24O2

Sample: Exemestane Powder

Keywords: Exemestane Powder, Exemestane Raw Material, Exemestane Powder Supplier

Henrikang offers Exemestane Powder Raw Material, and Exemestane Raw Powder Manufacturer, Exemestane Powder Supplier, Provide customized services for customers. Exemestane is indicated for postmenopausal women with estrogen-progesterone receptor-positive advanced breast cancer.

Exemestane Usage And Synthesis
Exemestane Overview:
Exemestane Powder is an irreversible steroidal aromatase inhibitor structurally similar to its substrate natural androstenedione. Estrogen deprivation through inhibition of aromatase is an effective and alternative treatment for hormone-dependent breast cancer in postmenopausal women Exemestane Raw Material is indicated for natural or artificial disease that has not progressed after tamoxifen treatment Advanced breast cancer in postmenopausal women. This product has no obvious effect on the biosynthesis of adrenocortical hormone, even if the concentration is 600 times higher than the concentration of inhibiting aromatase, it has no obvious effect on other enzymes in the corticosteroid production pathway. Exemestane is an oral, highly potent, irreversible steroidal aromatase inhibitor. Exemestane is a pharmaceutical raw material, an irreversible steroidal aromatase inactivator, which can inhibit the synthesis of estrogen and reduce the level of estrogen in blood circulation. It is suitable for postmenopausal late breast cancer patients whose disease has progressed after treatment with tamoxifen cancer patients.

Exemestane Actions and Uses:
Exemestane is a steroidal aromatase inactivator, its structure is similar to the natural substrate of aromatase androstenedione, and it is a pseudo-substrate of aromatase. Since estrogen in postmenopausal women is mainly produced by the conversion of androgen (produced by the adrenal cortex) under the action of aromatase in peripheral tissues, this product is irreversibly combined with the active site of aromatase to inactivate it, thus significantly Reduces circulating estrogen levels in postmenopausal women. This product has no obvious effect on the biosynthesis of adrenocortical hormone, even if the concentration is 600 times higher than the concentration of inhibiting aromatase, it has no obvious effect on other enzymes in the corticosteroid production pathway. This product is rapidly absorbed orally, and the absorption is affected by food. The oral bioavailability is 42%. Postmenopausal women have a higher absorption rate of the drug than healthy subjects. Patients reach the peak plasma concentration 2 to 4 hours after oral administration of this product, and the peak time is 1.2 hours on average, which is shorter than healthy subjects (2.9 hours). It is mainly bound to α1-acid glycoprotein and protein, and the total protein binding rate is 90%. Mainly metabolized by the liver, the metabolite is inactive 17-hydroexemestane, and the elimination half-life is 24 hours. It is mainly excreted through urine or feces, each accounting for 42% of the dose.

The chemical name of Exemestane is 1,4-diene-3,17-diene-6-methyleneandrostane or 6-methyleneandrostane-1,4-diene-3,17-dione, which is white or off-white crystalline powder; odorless. Soluble in chloroform, soluble in ethyl acetate, acetone, methanol or ethanol, almost insoluble in water. It is clinically applicable to postmenopausal patients with advanced breast cancer whose disease has progressed after tamoxifen treatment.

Pharmacological effects of exemestane:
The growth of breast cancer cells may be dependent on the presence of estrogens, circulating estrogens (estrone and estradiol) in postmenopausal women, mainly through the conversion of aromatase in peripheral tissues to androgens (androgen ). ketone and testosterone) from conversion. Blocking estrogen production by inhibiting aromatase is an effective and selective treatment for postmenopausal hormone-dependent breast cancer. Exemestane is an irreversible steroidal aromatase inactivator that is structurally similar to the natural substrate of androstenedionase. It combines with inactivation of acupoints (an effect also known as "self-destruct inhibition"), which significantly reduces circulating estrogen levels in postmenopausal women, but has no significant effect on adrenal corticosteroid and alsterol biosynthesis Effects. No significant effect on other enzymes in the steroidogenesis pathway when the concentration is 600 times higher than the concentration that inhibits aromatase.

Generic Name: Exemestane Tablets
Product name: Exemestane
English name: Exemestane Tablets
Pinyin: Yiximeitan Pian
Main ingredients and chemical names of this product: 6-methyleneandrost-1,4-diene-3,17-dione
Molecular formula: C20H24O2
Molecular weight: 296.41