Mitiglinide Calcium Raw material Mitiglinide Calcium Powder

CAS:207844-01-7

MF:C38H52CaN2O8

MW:704.91

EINECS:1308068-626-2

Specification: 99% min Mitiglinide Calcium Powder

Sample:Mitiglinide Calcium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Mitiglinide Calcium Powder Usage and Synthesis.

Miglinide calcium can close the K+-ATP channel on pancreatic islet β-cells, increase intracellular Ca2+ concentration and degranulate extracellular insulin-containing vesicles, thus stimulating insulin secretion.

In vitro experiments show that Miglinide calcium can stimulate insulin secretion from isolated hamster islet cells.

Electrophysiological studies have shown that it inhibits the opening of ATP-sensitive K+ channels, which can be completely blocked at a concentration of 10 μmol/L, and can stimulate the entry of Ca2+ into cells.

In the presence of glucose, Miglinide calcium dose-dependently stimulates insulin secretion from the isolated pancreas and isolated perfused pancreas of rats.

Miglinide and nateglinide are both rapid-acting proinsulinotropic drugs, but miglinide exhibits a more significant amelioration of postprandial hyperglycaemia.

This difference in efficacy is demonstrated by the fact that miglitazone promotes insulin secretion from HIT-T15 cells approximately 100 times more than nateglinide, and has a more pronounced insulin-promoting effect than nateglinide in animals with type II diabetes mellitus.

Uses of Mitiglinide Calcium.

Miglinide calcium stimulates insulin secretion from the pancreas rapidly and briefly only during meals, with a rapid onset of action and short duration of action; traditional oral diabetes medications stimulate insulin secretion continuously and excessively, especially between meals, often making the patient feel hungry, and with sulphonylpulse medications the patient is even encouraged to take a snack in between meals to give the excess insulin something to metabolise.

This extra eating causes patients to gain weight, and they are often obese to begin with.

Pharmacological Effect of Mitiglinide Calcium.

Miglitazone binds to pancreatic β-cell sulfonylurea receptors and inhibits ATP-sensitive K+ channels on the pancreatic β-cell membrane, resulting in cellular depolarisation and an increase in intracellular Ca2+ concentration, which promotes insulin secretion and lowers blood glucose.

Product Method of Bulk Mitiglinide Calcium Powder.