Clotrimazole Raw Materials powder

CAS:23593-75-1

MF:C22H17ClN2

MW:344.84

EINECS:245-764-8

Specification​: 99% min Clotrimazole powder

Sample:Clotrimazole powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Clotrimazole powder Usage and Synthesis.

Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi, and can also have bactericidal effect when the concentration is high.

Clotrimazole by interfering with the activity of cytochrome P450, thus inhibiting the biosynthesis of sterols such as ergosterol; damage to the fungal cell membrane and change its permeability, resulting in the leakage of important intracellular substances; can also inhibit the biosynthesis of fungal glycerol trisaccharides and phospholipids; the product can also inhibit the oxidative and peroxidase activity, resulting in an excessive accumulation of peroxides in the cell, resulting in the fungal subcellular structure of degeneration and necrosis.

Clotrimazole has broad-spectrum antifungal activity, it has good antimicrobial effect on Sclerotium epidermidis, Trichophyton rubrum, Aspergillus, Stachybotrys, Cryptococcus spp. and Candida spp. It also has certain antimicrobial activity on Schenk's spore filamentous fungi, dermatophytes, coccidia, and tissue plasmacytomycetes.

Uses and functions of Clotrimazole powder.

Clotrimazole is a broad-spectrum antifungal drug with significant inhibitory effects on a wide range of fungi, including Trichophyton rubrum, Trichophyton gypsum, Cryptococcus neoformans, Aspergillus, Algae, and Candida albicans.

Its mechanism of action is mainly to interfere with the activity of cytochrome P-450 of fungi, thus inhibiting the biosynthesis of ergosterol on the fungal cell membrane.

In addition, clotrimazole can dissolve keratin, increase protein hydration, with antipruritic, antimicrobial and other effects, and can increase the penetration of drugs through the skin.

Clotrimazole has good antibacterial effect on Scleroderma epidermidis, Trichophyton rubrum, Aspergillus, coloring fungi, Cryptococcus spp. and Candida spp. It also has a certain antibacterial activity on Schenk's spore filamentous bacteria, dermatophyte, Coccidioides vulgaris and Histoplasma capsulatum.

In conclusion, Clotrimazole is a kind of drug that can inhibit the growth and reproduction of many kinds of fungi.

Pharmacological effect of action of Clotrimazole powder.

In vivo and in vitro clotrimazole on Candida, Cryptococcus, Aspergillus, Algae, dermatophytes, etc. have good bacteriostatic effect, the efficacy of superficial fungal diseases of the skin is similar to ashwagandha, and the efficacy of deep fungal diseases is similar to amphotericin B. For visceral pathogenic fungi, such as Candida albicans, Cryptococcus neoformans, coccus spores, and histopathogenic fungi, are good, and for Candida albicans, the action is stronger than that of the bacteriostatic fungus. It has good effect on Candida albicans than mycotoxin. Fungus is not easy to produce drug resistance to this product.

It is easily absorbed internally and can be used internally for the treatment of systemic and deep fungal infections, such as Aspergillus fumigatus, Candida albicans, Cryptococcus, Coccidioidomycosis, Histoplasmosis (dogs, cats) and fungal sepsis. For serious deep fungal infections, it should be used in combination with amphotericin B.

External use can also be used to treat superficial fungal infections, such as ringworm and livestock ringworm, ringworm. It is not effective for ringworm of the head. Clotrimazole is also effective against certain gram-positive bacteria and trichomonas vaginalis.

Product Method of Bulk Clotrimazole powder.

It is obtained from o-chlorobenzoic acid by esterification, addition, hydrolysis, chlorination and condensation. It can also be obtained from o-chlorotoluene by chlorination to o-chlorotrichlorobenzene, then condensed with benzene in the presence of aluminum trichloride to produce diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.