Celecoxib Powder CAS 169590-42-5 Raw Materials

CAS:169590-42-5

MF: C17H14F3N3O2S

MW:381.37

EINECS: 685-962-5

Specification​: 99% min Celecoxib 

Sample: Celecoxib Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Celecoxib Powder Usage and Synthesis.

Celecoxib Powder is a new generation non-steroidal anti-inflammatory analgesic that inhibits prostaglandin production through selective inhibition of cyclooxygenase-2 (COX-2) to achieve anti-inflammatory and analgesic effects. Celecoxib Powder is a new generation non-steroidal anti-inflammatory analgesic that inhibits prostaglandin production through selective inhibition of cyclooxygenase-2 (COX-2) to achieve anti-inflammatory and analgesic effects.

Celecoxib CAS 169590-42-5 trade name is: Celebrex, Celebrex, this product has significant analgesic and anti-inflammatory effects with minimal incidence of upper gastrointestinal Celecoxib Raw Materials is used in the treatment of arthritis and has anti-inflammatory and analgesic effects and Celecoxib Raw Material is used in the treatment of arthritis and has Anti-inflammatory and analgesic effects and relieves signs and symptoms of osteoarthritis and rheumatoid arthritis.

Application/Function of Celecoxib Powder.

Celecoxib Powder and rofecoxib are two specific inhibitors of cyclooxygenase-2 (COX-2) that are commonly used in clinical practice. The incidence of upper peptic ulcers and other complications is minimal.

Celecoxib Powder is a non-steroidal anti-inflammatory drug that exerts Anti-inflammatory and analgesic effects by inhibiting cyclooxygenase-2 (COX-2), which blocks the synthesis of prostaglandins from arachidonic acid. It is clinically indicated for the treatment of acute and chronic osteoarthritis and rheumatoid arthritis.

Pharmacological Effects of Celecoxib Powder

Celecoxib has the Anti-inflammatory and analgesic effects of NSAIDs. Due to its chemical structure, it binds to COX-2 and has a selective inhibitory effect on COX-2.

The phenyl group of celecoxib binds to the hydrophobic channel of COX-2, and the hydrophilic sulfonamide group forms a hydrogen chain with the arginine at position 513 and histidine at position 90 in the "side pocket" of COX-2.

It also binds closely to the arginine at position 120 of COX-2 and inhibits the conversion of arachidonic acid into prostaglandins, which is unfavorable to human body, by COX-2. Due to the subtle difference in the structure of COX-1 and COX-2, the drug cannot enter the molecule of COX-1 and cannot inhibit the conversion of arachidonic acid into prostaglandins by COX-1.

Therefore, it has good anti-inflammatory and analgesic, protects gastric mucosa, maintains renal blood flow, regulates platelet coagulation, and solves the GI tract irritation effect of commonly used NSAIDs.