Pharmaceutical Clotrimazole Raw Materials Powder CAS 23593-75-1 API Factory Supply

CAS:23593-75-1

MF: C22H17ClN2

MW: 344.84

EINECS:  245-764-8

Specification​: 99% min Clotrimazole 

Sample: Clotrimazole Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Clotrimazole Powder Usage and Synthesis.

Clotrimazole Powder is a synthetic pyrrole antifungal, Clotrimazole Raw Materials has inhibitory effects on a wide range of pathogenic fungi, and can also be bactericidal at high concentrations. 

Clotrimazole CAS 23593-75-1 is a broad-spectrum antifungal agent used for systemic fungal infections, and is also used topically for localised fungal infections. Anti-mycobacterial agents, used for the treatment of epidermal and deep-seated mould infections, etc.

Uses and functions of Clotrimazole Powder.

Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi, and can also have bactericidal effect when the concentration is high.

Clotrimazole inhibits the biosynthesis of sterols such as ergosterol by interfering with the activity of cytochrome P450;

Damage to the fungal cell membrane and change its permeability, resulting in the leakage of important intracellular substances; can also inhibit the fungal biosynthesis of triglyceride and phospholipids;

The product can also inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in the cell, resulting in fungal subcellular structure degeneration and necrosis.

Clotrimazole has broad-spectrum antifungal activity, on the epidermis, trichophyton, trichophyton, colouring fungi, cryptococcus and Candida have good antibacterial effect, on the Schenk's spore filamentous bacteria, dermatitis bacterium, the genus of coarse coccobacillus, the organism plasma cell genus also has a certain antimicrobial activity.

Pharmacological Effects of Clotrimazole Powder.

(1) By reducing the activity of cytochrome P450, thus inhibiting the biosynthesis of sterols such as ergosterol in fungal cell membranes, damaging fungal cell membranes and changing their permeability, causing leakage of important intracellular substances.

(2)Clotrimazole can also inhibit the biosynthesis of triacylglycerol and phospholipids in fungi.

(3)It can also inhibit the activity of oxidase and peroxidase, leading to excessive accumulation of hydrogen peroxide in the cell, causing fungal subcellular structural degeneration and cell necrosis.

(4)It can inhibit the transformation of Candida albicans from spores to invasive hyphae.

Production method of Cimetidine Powder.

It is obtained from o-chlorobenzoic acid by esterification, addition, hydrolysis, chlorination and condensation. It can also be obtained from o-chlorotoluene by chlorination to o-chlorotrichlorobenzene, then condensed with benzene in the presence of aluminium trichloride to produce diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.