Theophylline Anhydrous Raw Materials Powder

CAS:25122-46-7

MF: C25H32ClFO5

MW: 466.97

EINECS: 246-634-3

Specification​: 99% min Theophylline Anhydrous Powder

Sample: Theophylline Anhydrous Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Theophylline Anhydrous Powder Usage and Synthesis.

Theophylline is commonly used in the treatment of angina and is used topically to relax smooth muscle. Theophylline also increases melanocyte activity and accelerates melanin formation. Copper gluconate is a potentiator of theophylline. Theophylline is used in hair water can be auburn hair, to prevent the generation of grey hair, and the odd number of carbon atoms of long-chain fatty acids or alcohols with better results. Theophylline has anti-inflammatory properties and can be used in conjunction with hydroglycerol extracts of seaweed to treat cellulitis.

Uses and functions of Theophylline Anhydrous Raw Powder.

Biochemical research, intermediates for synthesis of drugs such as caffeine.

Phosphodiesterase inhibitor, methyl purine drugs. It has the effects of cardiotonic, diuretic, dilating coronary artery, relaxing bronchial smooth muscle and excitation of central meridian system. Mainly used in the treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnoea.

Mainly used in the treatment of bronchial and cardiac asthma, also used in cardiogenic oedema.

Pharmacological Effects of Theophylline Anhydrous Raw Materials Powder.

The pharmacological effects of theophylline are related to blood concentration. The safety range of its effective blood concentration is very narrow, such as blood concentration of 10-20 μg/ml when the expansion of bronchial tubes, more than 20 μg/ml that can cause toxic reactions.Oral absorption is unstable, its in vivo contouring influencing factors, and individual differences are very large, the concentration in the blood is more difficult to control, so it is easy to occur poisoning.If the dosage is too large, or the speed of intravenous injection is too fast, or the effect of repeated use of the drug is accumulated, there is a possibility of overdose poisoning. And sometimes the symptoms of poisoning are not easy to be found, and even misdiagnosed as the original disease itself; and therefore wrongly further increase the dosage of theophylline, resulting in serious poisoning. Infections can affect theophylline metabolism, increase the concentration in the blood to reach the toxic level. Other factors that can increase theophylline blood concentration are: liver disease, congestive heart failure, respiratory failure, chronic obstructive pulmonary disease, renal failure, metabolic acidosis, hyperthermia, female, young, old and obese. It has been emphasised that intravenous aminophylline in the elderly is prone to toxicity, so it is not advisable to give this drug intravenously to the elderly.

Production method of Theophylline Anhydrous Raw.

(1) 1,3-dimethyl-4-amino-5-formamido uracil reacted with sodium hydroxide solution at 90-95°C to produce the crude product of theophylline, which was recrystallised by hot water and decoloured by activated carbon to obtain the finished product.

(2)Take ethyl cyanoacetate and dimethyl urea as raw materials, condensation, nitrosation, reduction, formylation, cyclization reaction to get the crude product, and then recrystallised to get.