CDP-Choline / Cytidine 5-Diphosphocholine CAS 987-78-0 Raw Materials Powder

CAS: 987-78-0

MF: C14H26N4O11P2

MW: 488.33

EINECS: 213-580-7

Specification​: 99% min CDP-Choline / Cytidine 5-Diphosphocholine

Sample: CDP-Choline / Cytidine 5-Diphosphocholine Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

CDP-Choline Powder Usage and Synthesis.

CDP-Choline Powder, chemically known as Cytidine 5-Diphosphocholine Powder, is a precursor of lecithin biosynthesis, which is significantly reduced Disorders of consciousness, tremor palsy, neurological deafness and tinnitus, as well as sleeping drug It also has good effect on Parkinson's syndrome and cerebral thrombosis hemiplegia.

cytosine-5'-diphosphate is the chemical name for cytidine cytosine-5'-diphosphate monosodium salt, which is a precursor of lecithin biosynthesis and is significantly reduced in brain tissue when brain function decreases.

cytosine-5'-diphosphate​​​​​​​ Powder stabilizes cell membranes by stimulating S-adenosyl-L-methionine, which increases dendritic complexity and spine density of motor neuron structures and improves neural plasticity in non-damaged areas.

Cytidine stabilizes cell membranes by stimulating S-adenosyl-L-methionine, increases dendritic complexity and spine density of motor neuron structures, improves neural plasticity in non-damaged areas, and promotes functional recovery;

Cytidine 5-Diphosphocholine Powder increases phospholipids by upregulating phosphocholine cytidylyltransferase (CCT), reducing the level of water-soluble phospholipids, and inhibiting secretory phospholipase A2 (PLA2) activity or by inhibiting PLA2 activation and reducing phospholipid loss through inhibition of TNF-a/IL-1b synthesis of lecithin and repair of neuronal cell membranes;

It also increases the expression of anti-apoptotic factors such as Bcl-2 and inhibits glutamate release to reduce cytotoxicity; promotes rapid repair of damaged cell surfaces and mitochondrial membranes, maintains cellular compactness and biological function, as well as reduces the release of free fatty acids, thereby reducing the production of toxic oxygenated metabolites as well as free radicals;

It increases vasopressin and plasma adrenergic levels and stimulates the release of growth hormone, thyrotropin and luteinizing hormone.

Application/Function of CDP-Choline Powder.

CDP-Choline Powder is mainly used for metabolic disorders after craniocerebral trauma and brain surgery, consciousness disorders, tremor paralysis, neurological deafness and tinnitus, as well as sleeping drug poisoning. It is also effective for Parkinson's syndrome and cerebral thrombosis hemiplegia.

CDP-Choline Powder is a mononucleotide composed of nucleic acid, cytosine, pyrophosphate and choline, which is mainly used in clinical treatment of various neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. Some studies have also shown that cytocholine can increase the brain's uptake of dopamine and glutamate, thereby improving cognitive performance.

Cytocholine also reduces the release of free fatty acids and restores the activity of mitochondrial ATPase and cell membrane Na+/K+ ATPase, thereby alleviating brain damage. However, the pathophysiological mechanisms of neurodegenerative diseases are complex and involve cholinergic deficiency, excitotoxicity of glutamate, neuroinflammation, immune dysregulation, hypoglucose metabolism, and disruption of the blood-brain barrier.

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There are more methods for the preparation of sodium cytophosphatidylcholine, mainly three routes. One is the microbial fermentation method. This method has the problems of low product concentration and unstable yield. One is the organic chemical synthesis method. This method is difficult to separate the product from the condensation agent, not suitable for pharmaceutical use, low reaction conversion rate, many by-products, high cost and serious environmental pollution.

There is also an enzymatic synthesis method, such as the use of brewer's yeast mud and other microorganisms for biosynthesis. Using free brewer's yeast mud cells for enzymatic synthesis, the process is simple, high conversion rate and low cost. The production process of sodium cytosine synthesis by enzymatic synthesis can be divided into two major parts: enzymatic synthesis process and extraction and purification process.