Supply Hydroxychloroquine sulfate 200mg Raw Materials powder

CAS:747-36-4

MF:C18H28ClN3O5S

MW:433.95

EINECS:212-019-3

Specification: 99% min Hydroxychloroquine sulfate

Sample:Hydroxychloroquine sulfate powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Ausreson

Appearance:white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Hydroxychloroquine sulfate of Usage and Synthesis.

Hydroxychloroquine sulfate is a slow acting antirheumatic drug of 4-helium-quinolines. It has been used for the prevention and treatment of malaria, but now it is generally used for the treatment of discoid and systemic lupus erythematosus. Its mechanism of action may be related to its immunosuppressive and anti-inflammatory effects.

Mechanism of action

Lysosomal pH elevation: alters antigen processing

Immunomodulation: reduces cytokine production

Antiviral effects: may inhibit viral entry/fusion (controversial)

Antimalarial effects: concentrated in parasite food vacuoles

Dosage Guidelines

Standard Dosage

Malaria Prophylaxis: 400 mg weekly

RA/SLE: 200-400 mg daily

COVID-19*: 400 mg bid on day 1, then 200 mg bid (not FDA approved)

Special Populations

Renal Impairment: reduce dose by 50% if CrCl <30mL/min

Hepatic Impairment: monitor closely

Pediatrics: 5 mg/kg (400 mg max)

Uses of Hydroxychloroquine sulfate.

First, anti-inflammatory

1. Inhibit the release of inflammatory mediators: hydroxychloroquine sulfate can inhibit the generation and release of leukotrienes, which can reduce the discomfort caused by inflammatory response. In addition, the drug can also play an anti-inflammatory role by inhibiting the activity of cyclooxygenase-2 to reduce prostaglandin synthesis.

​Second, immune regulation

Hydroxychloroquine sulfate can regulate the immune function of the body by affecting the production and secretion of cytokines, and is mainly used in clinical treatment of systemic lupus erythematosus and other autoimmune diseases.

​Third, anti-malaria

Hydroxychloroquine sulfate is an effective antimalarial drug that can kill parasites by blocking their hemoglobin synthesis. At the same time, the drug also has certain anti-inflammatory, analgesic and antipyretic effects.

​It should be noted that due to the existence of individual differences, some patients may have some adverse reactions after taking it, such as headache, nausea, vomiting, diarrhea, rash, etc. If the symptoms are mild, there is generally no need for special treatment, but if the symptoms are severe, it is necessary to stop the drug in time and seek medical treatment.

What are the side effects of hydroxychloroquine sulfate tablets?

Muscle weakness, cramps, stiffness or spasms, or changes in skin sensation, such as tingling. Frequent infections, high fever, sore throat or mouth ulcers.

What should I avoid when taking hydroxychloroquine?

• Cautions with other medicines
• azithromycin, erythromycin or clarithromycin, antibiotics.
• amiodarone or digoxin, medicines for heart problems.
• medicines for epilepsy.
• medicines for diabetes, such as insulin or metformin.
• cimetidine, a medicine for stomach ulcers.

Frequently Asked Questions

Q: What is the difference between hydroxychloroquine and chloroquine phosphate?

A: Hydroxychloroquine has a better safety profile and a lower risk of ocular toxicity.

Q: What is the minimum order quantity for research purposes?

A: Typically 25 grams for analytical purposes

Q: What are the available salt forms?

A: Sulfate is the standard salt; phosphate form is also available

Q: Is documentation provided?

A: A complete COA, MSDS and CofA are provided with each batch.

Q: Solution stability?

A: Stable in NS/D5W for 24 hours at room temperature.

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