Raw Materials Corydalis Extract Powder

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Specification: 99% min Corydalis Extract

Sample:Corydalis Extract

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Corydalis Extract Powder Usage and Synthesis.

Yanhusuo Extract is the dried tuber extract of CorydalisyanhusuoW.T.Wang, a perennial herb of the poppy family. The total alkaloids of CorydalisyanhusuoW.T.Wang are the main pharmacodynamic substances, of which CorydalisyanhusuoE is the main active ingredient, with analgesic, sedative, hypnotic and sedative, anxiolytic and local anaesthesia, antispasmodic effect on coronary arteries, antidysrhythmic, antimuscarinic, CorydalisyanhusuoE in a greater than the effective dose of the inhibition of gastric juice secretion.

Uses and functions of Corydalis Extract.

After depolarisation, CA2+-induced contraction of the uterus has an obvious relaxing effect, inhibit the formation of pulmonary hypertension and delay the remodelling of pulmonary artery vessels;

Dehydrozincine has the effect of improving the hypoxia tolerance of mice;

Bamatine has anti-adrenaline and anti-norepinephrine effects. The analgesic efficacy of the three fenugreeks, alpha-, beta-, and uglifloxacin, was stronger for uglifloxacin, followed by beta-, and weakest for alpha-, beta-, and uglifloxacin.

The analgesic effects of etanercept, ugliflozin and decanercept were most pronounced for etanercept, followed by ugliflozin and worst for decanercept. In addition, it was shown that YhsP-1, a polysaccharide extracted from the rhizomes of Yanhusuo, was able to inhibit the growth of sarcoma 180 and leiws lung cancer in mice.

Pharmacological Effect of Corydalis Extract.

1. Effects on cardiovascular and cerebrovascular

Yanhusuo extract has the pharmacological effects of dilating coronary arteries, increasing coronary blood flow, inhibiting platelet aggregation, antiarrhythmia, improving myocardial oxygen supply and increasing cardiac output.

Through coronary artery ligation to manufacture rat heart failure model, observe the effect of fenugreek extract on the heart failure model, found that it can reduce the area of myocardial infarction, reduce the left ventricular end-diastolic pressure, increase the maximum rate of rise of the left ventricular intraventricular pressure, and can be significantly low left ventricular/body weight ratio, lung/body weight ratio, inhibit the activity of neurohormones.

The intervention effect of fenugreek on myocardial ischemia-reperfusion arrhythmia in preconditioned rats was found that fenugreek preconditioning could antagonise ischemia-reperfusion-induced changes in the ST segment of the electrocardiogram, and markedly reduce the magnitude of ST segment elevation, suggesting that fenugreek preconditioning has a certain antagonistic effect on myocardial ischemia-reperfusion arrhythmia in rats.

Further study found that the pretreatment of fenugreek can reduce the opening of L-type calcium channels on the myocardial cell membrane, inhibit the inward flow of extracellular calcium ions, and avoid intracellular calcium ion overload, which may be the mechanism of action of the pretreatment of fenugreek to prevent and control reperfusion injury.

2.Effects on digestive system

Some components of the extract of fenugreek have a protective effect on experimental gastric ulcers, and its active ingredients are mainly fenugreek ethylin, dehydrofenugreek methylin and proto-opioid alkaloids, which can reduce the amount of gastric juice, gastric acid secretion, reduce the activity of pepsin, pylorus ligation or aspirin and other causes of gastric ulcers induced by a variety of reasons, there is a significant protective effect.

And there are experiments to prove that Yanhuisuo hasin has an inhibitory effect on gastric acid and histamine-stimulated acid secretion in in vitro rats, and has the function of inhibiting acid secretion of gastric mucosa and gastric wall cells in isolated rats.

Its antagonistic effect is different from that of cimetidine, which is a competitive antagonism; while Yanhuosuosu has been able to make the maximum acid secretion reaction decline, non-competitive inhibition.

3.Anti-tumour effect

The total alkaloid of Yanhuosuo has a dose-dependent inhibitory effect on a variety of human gastric cancer cell lines, and further studies found that different concentrations of total alkaloid of Yanhuosuo can induce apoptosis of MKN-228 cells, suggesting that apoptosis may be one of the main mechanisms of the anti-tumour effect of total alkaloid of Yanhuosuo.

The in vitro cytotoxic activity of the alkaloids of Yanhusuo was isolated and measured against hepatocellular carcinoma cells SMMC-7721, and it was found that the fat-soluble non-phenolic alkaloid fraction of Yanhusuo had the strongest killing activity against liver tumour cells, and had the highest growth inhibitory activity against SMMC-7721, with an IC50 of about 35 μg/ml.

Preparation method of Bulk Corydalis Extract Powder.

Weigh 5g of Yanhusuo, respectively, distilled water, 50% ethanol soaked overnight, centrifuged to discard the precipitation, crude extract, concentrated to 25mL under reduced pressure, the solution were extracted with n-butanol, ethyl acetate, petroleum ether, ethyl ether, full shaking, static until the two phases of the liquid surface is completely separated.

With Separate the organic solvent phase from the aqueous phase with a separatory funnel, collect the organic solvent, concentrated under reduced pressure and dissolved in sterile water, can be obtained Yanhusuo extract.