Raw material Coltsfoot Leaf Extract powder

CAS:84625-50-3

MF:/

MW:/

EINECS:283-420-9

Specification: 99% min Coltsfoot Leaf Extract powder

Sample:Coltsfoot Leaf Extract powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Coltsfoot Leaf Extract powder Usage and Synthesis.

Winterflower is a kind of Chinese herbal medicine, and its extract has the effect of moistening the lung and lowering the qi, resolving phlegm and relieving cough. Not only can the extracts of the flowers treat new and old coughs, asthma and coughing up blood, but according to modern research, the extracts also have a certain degree of elevation of blood pressure, excitation of respiratory function and antiseptic effect.

Uses of Coltsfoot Leaf Extract powder.

1. Cough suppressant effect: Winterflower has cough suppressant effect, ether extract has antispasmodic effect on histamine-induced bronchospasm, but the effect is weaker than that of aminophylline.

2. Expectorant effect: Animal test proved that the decoction of Flos Daturae can promote the increase of respiratory secretion, and has obvious expectorant effect.

3. Effects on smooth muscle: The ether extract of Flos Daturae is inhibitory to both in vitro and isolated gastrointestinal smooth muscle. For isolated uterus, the alcohol extract excites in small amount, and excites and then inhibits in large amount, or inhibits at the beginning.

4. Effect on blood pressure: the alcoholic extract of Flos Daturae has the effect of lowering and then raising the blood pressure.

Pharmacological Effect of Coltsfoot Leaf Extract powder.

1. Effects on the respiratory system: the decoction of Hibiscus sabdariffa by gavage has obvious antitussive effect on dogs. Its ethyl acetate extract has expectorant effect, ethanol extract has analgesic effect.

Its ether extract on the rabbit respiratory effect similar to niclosamide, can counteract morphine-induced respiratory depression. Antispasmodic effect on histamine-induced bronchospasm.

2. Effects on the cardiovascular system: the alcoholic extracts and decoctions of flowers intravenous injection, the cat's blood pressure was first a short micro-drop, followed by a sharp rise, and maintained for a longer period of time.

The ether extract has a stronger pressure-raising effect. For anaesthetized cats, rabbits, dogs and rats, etc., static injection, can be seen in respiratory excitation, heart rate increases, blood pressure rises sharply, the blood pressure of cats in haemorrhagic shock, especially obvious.

The spinal cord cat can be significantly elevated, the cat vertebral artery injection, it is lowered, and its lowering effect is not affected by the six hydrocarbon quaternary amine, but by the phentolamine and rifampicin attenuated.

Chlordecone caused contraction of the aortic strip in rabbits, and its action was not blocked by phentolamine or verapamil, but was significantly attenuated in Ca2+-free solution. This indicates that the site of its antihypertensive action is in the periphery.

3. Effects on gastrointestinal and uterine smooth muscle: The ether extracts of Hordeum vulgare have inhibitory effects on gastrointestinal smooth muscle, and can counteract the contraction of intestinal tubes induced by barium chloride; on the in situ and isolated uterus, it is excited in small doses, but is inhibited in large doses, or is inhibited after excitement.

4. Inhibition of platelet aggregation: the phorbol esculent Ⅰ, Ⅱ, Ⅲ, isolated from the flowers, have inhibitory effect in the platelet aggregation experiment caused by platelet activating factor. In the calcium channel blocker receptor binding test, there is also a blocking effect on the activity of phorbol esculent Ⅰ.

5. Effects on the central nervous system: ether extracts of Aspergillus oryzae used in frogs, toads, mice, rats, guinea pigs and rabbits can cause agitation, respiratory excitement, muscle tension, tremors, clonus, and finally convulsions and death. Convulsions are caused by over-excitation of the central nervous system.

6. Other effects: the static injection of the preparation, in the rise in blood pressure at the same time, can be seen in the pupil dilation, increased secretion of the lacrimal gland and tracheal glands, limb muscle tension.

Preparation of Bulk Coltsfoot Leaf Extract powder.

Take dry flower buds 1kg crushed, add 4L petroleum ether (distillation range 60-90 ℃) soaking at room temperature 5h, ultrasonic extraction 3 times, each time 60min, the extract is filtered, concentrated to dry under reduced pressure, get 1.31g of extract, that is, the extracts of the flowers of the winter flowers applied to asthma treatment.