Mildronate CAS 76144-81-5 Raw Powder

CAS: 76144-81-5

MF: C6H14N2O2

Specification​: 99% min Mildronate Powder

Sample:  Mildronate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Mildronate Powder Usage and Synthesis:

Mildronate, also known as Meldonium, is a medication that is primarily used to treat heart conditions such as angina and heart failure. It was developed in Latvia in the 1970s and is now produced by several pharmaceutical companies.

Mildronate works by improving blood flow and increasing oxygen delivery to the body's tissues. It is believed to do this by inhibiting the breakdown of a substance called carnitine, which plays a key role in energy metabolism.

In recent years, Mildronate has gained attention as a potential performance-enhancing drug. It has been banned by the World Anti-Doping Agency (WADA) since January 2016, as it is believed to enhance endurance and aid recovery after exercise.

However, the use of Mildronate for performance enhancement remains controversial, and there is limited scientific evidence to support its effectiveness in this regard. Its use is also associated with potential side effects, including nausea, headache, and dizziness.

Overall, Mildronate is a medication that is primarily used to treat heart conditions, but its use as a performance-enhancing drug remains controversial. It is important to consult with a healthcare professional before using Mildronate or any other medication.

Pharmacokinetics of Mildronate Powder:

1. Meldonium can improve the energy metabolism process of cardiomyocytes, inhibit carnitine dependent fatty acid oxidation, strengthen intracellular sugar metabolism, provide energy to tissues through anaerobic colysis, improve myocardial ischemia and hypoxia symptoms, and can be combined with other drugs (such as vasodilator, diuretic drugs, etc.) for the treatment of ischemic heart disease.

2. Meldonium can promote the redistribution of blood in the ischemic areas of the heart and brain, and is used for the treatment of various acute and chronic disorders of cerebral blood supply.

3. The drug can improve people's working ability and relieve psychological and physiological overstress syndrome by improving the process of fat metabolism. Athletes can improve their sports performance by taking the drug during training and competition.

4, eliminate the functional damage to the nervous system of patients with chronic alcoholism during the onset of withdrawal syndrome, in addition, the drug can also improve the retinal vascular disease caused by nutritional disorders.

5. Membrane protection: myocardial ischemia causes tension reaction of myocardial cells, resulting in increased decomposition of fatty acids in mitochondria, accumulation of fatty acid metabolites in cells, destruction of cell membrane apparatus, and increase of intracellular Ca++.

6. Energy optimization effect: Meldonium can reduce the accumulation of long chain acyl carnitine, thus inhibiting carnitine dependent fatty acid oxidation, transforming the energy metabolism of hypoxic myocardium from fatty acid oxidation to more favorable glucose oxidation, that is, promoting the anaerobic oxidation of glycolysis pathway, so this product has anti-hypoxia effect and cardiac protective activity.

7. Influence on energy metabolism enzymes: Meldonium can also prevent isoproterenol-induced enhancement of blood lactate dehydrogenase (myocardial specific isoenzyme) liver heteroactivity, prevent creatine phosphokinase activity increase.

8, the effect of carnitine excretion: Other studies have shown that meldonium in the body in addition to competitive inhibition of butyrate betaine hydroxylase, block carnitine biosynthesis, but also competitive impact of carnitine in the kidney reabsorption.

9. Protection of ischemic heart: In myocardial ischemic area, blocked anterior descending rami not only reduce ATP, ADP and myophosphate at tissue level, but also increase AMP and lactate at tissue level, reducing the value of energy load potential. The results show that meldonium can inhibit β-oxidation of fatty acids, which is beneficial to the energy metabolism of ischemic myocardium.

Applications of Argireline Powder :

Mildronate Powder also known as THP,  MET-88 and mildronate,Mildronate CAS 76144-81-5 is a new cardioprotective drug. Mildronate Powder is a structural  analogue of carnitine. Mildronate Powder is used as a raw material for cardiovascular diseases - stable angina,  chronic heart failure, cardiomyopathy and other diseases.

Meldonium (also known as THP, MET-88 and mildronate) is a new cardioprotective medicine. It is a compound with a novel structure that was first developed by Latvian Organic Synthesis. It was first marketed by Grindeks in 1989 in the former Soviet Union and is currently onate in Larovia, Russia, Ukraine, Belarus, Azerbaijan, Armenia, Moldova, Lithuania and other 15 countries listed, the drug is the structure of carnitine similar, can compete with carnitine γ-trimethylaminobutyl salt hydroxylase, reduce the concentration of free carnitine and long chain acetylcarnitine, so can inhibit carnitine dependent fatty acid oxidation process.

Cardiovascular diseases - Stable angina, chronic heart failure, cardiomyopathy, functional cardiovascular system failure; Acute and chronic ischemic attacks; Reduced working ability under high physical and emotional load; Convalescence after cerebrovascular disease, brain injury and encephalitis. Alcohol withdrawal symptoms.