Atorvastatin CAS 110862-48-1 Raw Materials Powder

CAS: 110862-48-1

MF: C33H35FN2O5

Specification​: 99% min Atorvastatin Powder

Sample: Atorvastatin Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Atorvastatin Powder Usage and Synthesis:

Atorvastatin Powder is a cholesterol-lowering drug ingredient that belongs to the statin class.Atorvastatin Raw Materials reduces cholesterol levels in the blood by inhibiting the activity of cholesterol synthase and reducing cholesterol synthesis in the liver.Atorvastatin CAS 110862-48-1 Atorvastatin is widely used to treat hypercholesterolemia and to prevent cardiovascular disease. It usually requires long-term use and needs to be supervised by a doctor as it may cause some side effects such as muscle pain and abnormal liver function.

Atorvastatin is used for the treatment of hyperlipoproteinemia, especially for the treatment of pure and heterozygous familial hypercholesterolemia, as well as for diabetic dyslipidemia, and is often used clinically as a primary and secondary prevention agent for coronary heart disease. Atorvastatin is a new synthetic, hydroxymethylglutarate monoacyl coenzyme A reductase inhibitor.

It can lower LDL and total cholesterol, lower triglycerides, and raise HDL cholesterol, and its absorption from food is basically unaffected. It has a very potent lipid-lowering effect, twice that of simvastatin. Currently, the main clinically recognized intensive lipid-lowering drugs include atorvastatin and resulvastatin.

Applications of Atorvastatin Powder :

Atorvastatin is an organic compound with molecular formula C33H35FN2O5 and molecular weight 558.65. Pure product is white crystalline powder, odorless, tasteless and easily soluble in water.

It is a selective competitive HMG-CoA reductase inhibitor that significantly reduces LDL-ch and triacylglycerol, but does not cause redistribution of triacylglycerol but a constant reduction of TG in all lipoprotein components. in completed clinical studies, it is more effective in reducing LDL-ch than other reported lipid-lowering drugs. the drug was first developed by Parke-Davis, Inc.

The drug was first developed by Parke-Davis in the US and approved by the US FDA as an Investigational New Drug (IND) in 1995, and was first marketed in the UK in February 1997.

Pharmacological Effect of Atorvastatin Powder:

Compound (I) was reduced with triethylboron and sodium borohydride in methanol and the product was rehydrated to give atorvastatin sodium. Acidification yields atorvastatin. And atorvastatin is refluxed in toluene with Dan-Stark hydrazine (Dan-Stark trap) for 20min to produce atorvastatin lactone.

Atorvastatin calcium tablets belong to the statin class of lipid-regulating drugs, which can play a role after application mainly by competitively inhibiting the rate-limiting enzymes in the process of cholesterol synthesis, which can reduce cholesterol synthesis and increase LDL receptor synthesis, and the main site of action is the liver, and the result is to reduce cholesterol and LDL cholesterol levels and increase HDL cholesterol. Therefore, it plays a very important role in the prevention and treatment of atherosclerosis and coronary heart disease.

Atorvastatin calcium tablets are mainly used clinically in patients with hypercholesterolemia, especially in primary hypercholesterolemia, including familial hypercholesterolemia or mixed hyperlipidemia. In general, adults should take 20mg-40mg once a day after dinner. During the course of administration, attention should be paid to monitoring adverse reactions, individual gastrointestinal discomfort may occur, but most of them are tolerable, and if rhabdomyolysis or severe hepatic or renal impairment occurs, the drug needs to be discontinued.