Candesartan Cilexetil CAS 145040-37-5 Raw Materials Powder

CAS: 145040-37-5

MF: C33H34N6O6

MW: 610.66

EINECS: 627-030-2

Specification​: 99% min Candesartan Cilexetil

Sample: Candesartan Cilexetil Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Candesartan Cilexetil Powder Usage and Synthesis.

Candesartan Cilexetil Powder is a precursor drug of candesartan, with 10 times the strength of action of losartan, good selectivity of action (more than 10,000 times higher affinity for AT1 receptors than AT2), long duration of action (1 dose per day), and relatively gentle release of active action in the Candesartan Cilexetan is a new drug that has been shown to have a higher affinity for AT1 receptors than AT2), long duration of action (1 dose per day), and relatively gentle release of active action in the body after oral administration due to being a precursor drug. 

Candesartan Cilexetil CAS 145040-37-5 is an ideal drug for the treatment of hypertension. Use: Anti-hypertensive pharmaceutical raw material. Candesartan Cilexetil Raw Materials is suitable for primary hypertension.

Hypertension has become a serious social problem due to its high incidence, high disability and mortality rates, and the resulting medical, social, family and economic burdens. The development of first-line drugs for the treatment of hypertension has become a focus of competition among major manufacturers worldwide.

Application/Function of Candesartan Cilexetil Powder.

Candesartan dispersible tablets are used to lower blood pressure. Candesartan, the main ingredient of this drug, is a precursor drug that is hydrolyzed into candesartan when it enters the body, thus exerting its therapeutic effect. Candesartan is an angiotensin II receptor antagonist. Angiotensin I is converted into angiotensin II, which is a substance that raises blood pressure and can constrict blood vessels.

Candesartan acts as an antagonist of the effect of angiotensin II by inhibiting the action of angiotensin II receptors. This drug can reduce the vasoconstrictive effect of angiotensin II, and thus can play a role in lowering blood pressure; it can also have a certain antihypertensive effect by inhibiting the secretion of aldosterone. Candesartan dispersible tablets are mainly used for patients with hypertension, either alone or in combination with other antihypertensive drugs.

Candesartan Cilexetil Powder ester is rapidly hydrolyzed in the body into the active metabolite candesartan, which is a selective angiotensin II receptor (ATl) antagonist that antagonizes the vasoconstrictive effect of angiotensin II by binding to vascular smooth muscle ATl receptors, thereby reducing peripheral vascular resistance. It is also believed that candesartan may exert some antihypertensive effects by inhibiting aldosterone secretion from the adrenal glands. Candesartan Cilexetil Powder does not inhibit kinase II and does not affect bradykinin degradation.

Trials in hypertensive patients showed that multiple doses of Candesartan Cilexetil Powder can increase plasma renin activity, angiotensin I concentration and angiotensin II concentration; 2-8mg of Candesartan Cilexetil Powder taken continuously once daily can decrease systolic and diastolic blood pressure, reduce left ventricular myocardial weight and peripheral vascular resistance, but have no significant effect on cardiac output, ejection fraction, renal vascular resistance, renal blood flow and glomerular filtration rate. In patients with essential hypertension with cerebrovascular disorders, there was no effect on cerebral blood flow.

Candesartan is an antihypertensive drug that is rapidly hydrolyzed in the body into the active metabolite candesartan, which is an angiotensin receptor antagonist that binds to angiotensin receptors in vascular smooth muscle and antagonizes the vasoconstrictive effect of angiotensin, thereby reducing peripheral vascular resistance and lowering blood pressure.

The usual dosage of candesartan in clinical application for adults is generally four to eight milligrams once a day, which can be increased to 12 milligrams a day if necessary.

Some patients may have electrolyte abnormalities leading to hyperkalemia, liver function abnormalities, kidney function abnormalities, granulocytopenia, rhabdomyolysis, interstitial pneumonia, but these cases are rare.

There is also a possibility that some patients may suffer from allergy, skin redness, itching, urticaria, may also lead to digestive symptoms such as nausea and vomiting, if allergic to the drug is prohibited, pregnant or may be pregnant women are prohibited to use.

The main action of Candesartanate Capsules is to lower blood pressure and has a very obvious adjunctive effect in the treatment of primary hypertension symptoms such as chest tightness, chest pain, panic, irritability, and dyspnea. Candesartanate capsule is composed of candesartanate Chinese medicine ingredients, is a capsule preparation, the contents of which are white or off-white granules or powder. Patients who experience severe symptoms such as muscle pain, difficulty in breathing, body fever, and decreased red blood cells after taking the medication should stop taking the medication immediately and seek medical attention promptly.