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Irbesartan raw Powder CAS 138402-11-6 Irbesartan
Product Overview:
Irbesartan is an inhibitor of AngiotensinⅡ (AngⅡ) receptor, which can be divided into AT1 and AT2. Irbesartan can inhibit AngⅠ conversion to AngⅡ by selectively blocking AnglI's AT1 receptor, and can specifically antagonize angiotensin-converting enzyme 1 receptor (AT1). The antagonistic effect on AT1 is 8500 times that of AT2. By selectively blocking the binding of AngⅡ to AT1 receptor, the vasoconstriction and aldosterone release are inhibited, resulting in antihypertensive effect. It does not inhibit angiotensin-converting enzyme (ACE), renin, and other hormone receptors, nor does it inhibit ion channels involved in blood pressure regulation and sodium balance. Irbesartan can also reduce myocardial electrical remodeling, thereby reducing the mortality of hypertensive patients, is currently the most effective drug for the treatment of hypertension and cardiovascular diseases.
Irbesartan raw Powder CAS 138402-11-6 Irbesartan Attributes
CAS:138402-11-6
MF:C25H28N6O
MW:428.53
EINECS:604-078-2
Specification: 99% min Irbesartan
Sample:Irbesartan Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Irbesartan raw Powder CAS 138402-11-6 Irbesartan Details
Irbesartan Usage and Synthesis.
Irbesartan, as a long-acting antihypertensive drug, is the first-line drug for hypertension, and in addition to treating hypertension, it has shown good efficacy for Parkinson's disease, diabetes and kidney disease.
Uses of Irbesartan.
Irbesartan is an angiotensin II receptor antagonist antihypertensive drug used for the treatment of essential hypertension and type 2 diabetes with hypertension
The disease is kidney disease.
This product can inhibit angiotensin II and AT1 receptor binding, inhibit vasoconstriction, reduce vascular resistance, reduce aldosterone secretion, plasma vascular tightness
The level of tensin II is increased, which plays a role in reducing blood pressure.
Drug interaction of Irbesartan.
Product Method of Irbesartan.
Method 1: (fluorenyl methoxy-carbonyl amino) cyclopentane carboxylic acid (I) aminated 4-(2-phenylcyanyl) benzylamine, and the product (Ⅲ) was rehydrated to remove the protective group on N, and compound (Ⅳ) was obtained. (Ⅳ) and triethyl orthobutyrate condensation ring to obtain compound (V), and then react with sodium azide to form tetrazole, to ebisartan.
Method 2:1 -(fluorenyl methoxycarbonyl amino) cyclopentocarboxylic acid (I) and compound (Ⅳ) condensation, the product removes the protective group on N to obtain compound (Ⅷ), and then reacts with triethyl protovalerate to obtain the product.
