Hrk supply Diltiazem hydrochloride Raw materials powder

CAS:33286-22-5

MF:C22H27ClN2O4S

MW:450.98

EINECS:251-443-3

Specification: 99% min Diltiazem hydrochloride powder

Sample:Diltiazem hydrochloride powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Diltiazem hydrochloride powder of Usage and Synthesis.

Diltiazide is a calcium channel blocker that acts on myocardium and vascular smooth muscle because it can inhibit calcium influx during depolarization. The pharmacological effects of this product are as follows:

It can effectively dilate the epicardial and subendocardial coronary arteries and relieve spontaneous angina pectoris or angina pectoris caused by coronary artery spasm induced by ergotrine.

By slowing heart rate and lowering blood pressure, reducing myocardial oxygen demand, increasing exercise tolerance and relieving exertional angina. It can relax the vascular smooth muscle, reduce the resistance of peripheral blood vessels, and reduce blood pressure: the amplitude of blood pressure reduction is related to the degree of hypertension, and the blood pressure of normal people only decreases slightly.

. Secondly, it has a negative inotropic effect and can slow down the conduction of the sinoatrial node and atrioventricular node.

. Dilate peripheral blood vessels and coronary arteries, and have a weak negative inotropic effect.

Uses of Diltiazem hydrochloride.

Calcium channel blocker, used for supraventricular arrhythmia, angina pectoris, elderly hypertension, etc. This product is a coronary dilator, effective for angina pectoris. It is used for the treatment of angina pectoris caused by exercise and old myocardial infarction. The oral LD50 of this product is 640 mg/kg for female mice and 560 mg/kg for male rats.

Pharmacological action of Diltiazem hydrochloride.

The effect of diltiazem is related to the inhibition of calcium influx during depolarization of myocardium and vascular smooth muscle. The product can effectively dilate the epicardial and subendocardial coronary arteries, relieve spontaneous angina pectoris or angina pectoris caused by coronary artery spasm induced by ergotrine; By slowing heart rate and lowering blood pressure, reducing myocardial oxygen demand, increasing exercise tolerance and relieving exertional angina. The product can relax the vascular smooth muscle, decrease the resistance of the peripheral blood vessels, and lower the blood pressure. The magnitude of blood pressure reduction is related to the degree of hypertension, and the blood pressure of normal people only slightly decreases. This product has a negative inotropic effect and can slow down the conduction of the sinoatrial node and atrioventricular node.

Product Methods of Bulk Diltiazem hydrochloride powder.

2- (4-methoxyphenyl) -3-hydroxy-1, 5-benzothiaze-4 (5H) -ketone was obtained from the condensation of 2-thiophenol with ethyl p-methoxyphenyl epopropionate. Thiazepenone is then synthesized by acylation, condensation with dimethylaminochloroethane, and salt.