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Antimalarial Raw Materials powder Hydroxychloroquine sulfate
Product Overview:
Hydroxychloroquine sulfate is an anti-malarial drug with anti-inflammatory, immunomodulatory and anticoagulant effects. At present, hydroxychloroquine is mainly used in the clinical treatment of rheumatoid arthritis, juvenile chronic arthritis, discoid lupus erythematosus and systemic lupus erythematosus, but the clinical effect is slow, often taking 2 to 4 months. The pharmacological action of this drug is not very clear, it may be related to the stabilization of lysosomal membrane, inhibition of prostaglandin formation, inhibition of chemotaxis of polymorphonuclear cells and phagocytosis, may interfere with the formation of monocyte interleukin-1 and inhibit the release of neutrophil superoxide
Antimalarial Raw Materials powder Hydroxychloroquine sulfate Attributes
CAS:747-36-4
MF:C18H28ClN3O5S
MW:433.95
EINECS:212-019-3
Specification: 99% min Hydroxychloroquine sulfate powder
Sample:Hydroxychloroquine sulfate powder
Packaging:1kg/bag, 25kg/drum
From:Henrikang
Appearance:white
Shelf Life: 2 Years
Test Method: HPLC
Antimalarial Raw Materials powder Hydroxychloroquine sulfate Details
Hydroxychloroquine sulfate powder Usage and Synthesis.
Hydroxychloroquine sulfate tablets are widely distributed in the eyes, kidneys, liver, lungs and other organs after oral administration, and can also pass through the placenta. The blood concentration reaches its peak in about 2 to 4.5 hours, and the concentration in red blood cells is 2 to 5 times higher than the plasma concentration. Some are metabolized in the liver as active deethylated metabolites. The plasma elimination half-life is about 32 days. It is mainly excreted through the kidney and excreted slowly, of which 23-25% is the original drug and can also be excreted with milk.
Composition only of Hydroxychloroquine sulfate powder.
Pharmacological action of Hydroxychloroquine sulfate powder.
Hydroxychloroquine sulfate has similar pharmacological action, pharmacokinetics and metabolic process as chloroquine. After oral administration, hydroxychloroquine is rapidly and almost completely absorbed. In one study, after a single dose of 400mg of hydroxychloroquine was given to healthy volunteers, the average plasma peak concentration was in the range of 53-208ng/ml, with an average level of 105ng/ml. The mean time for plasma to reach peak concentration was 1.83 hours. Depending on the time after administration, the mean plasma elimination half-life changes as follows: 5.9 hours, 26.1 hours, and 299 hours, respectively, at -10, 10-48, and 48-504 hours after peak plasma concentration. Parent compounds and metabolites are widely distributed in the body and are eliminated primarily through urine. In one study, 3% of the dose administered was observed over 24 hours.
Product method of Bulk Hydroxychloroquine sulfate powder.
