Pharmaceutical Etamsylate Raw Materials Powder CAS 2624-44-4 API Factory Supply

CAS:2624-44-4

MF: C10H17NO5S

MW: 263.31

EINECS:  220-090-7

Specification​: 99% min Etamsylate 

Sample: Etamsylate 

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Etamsylate Powder Usage and Synthesis.

Phenylethylamine also known as hemostat, its chemical name is 2,5-dihydroxybenzenesulfonic acid diethylamine salt, Etamsylate Powder works by promoting the process of coagulation.

Etamsylate Raw Materials is able to increase the number of platelets in the blood, enhance their aggregation and adhesion, and promote the release of coagulant substances to accelerate blood clotting. 

Etamsylate CAS 2624-44-4 is clinically used for the prevention and treatment of excessive surgical bleeding, thrombocytopenic purpura or allergic purpura, and other causes of bleeding.

Uses and functions of Etamsylate Powder.

Phenylethylamine can increase the number of platelets and enhance their aggregation and adhesion, promote the release of coagulant active substances from platelets, shorten the clotting time and accelerate the contraction of blood clots. In addition, it also has the effect of enhancing capillary resistance, reducing its permeability and decreasing blood exudation. 

The hemostatic effect of this product is rapid, the effect reaches the peak 1 hour after intravenous injection, and the efficacy can be maintained for 4 to 6 hours.

Pharmacological Effects of Etamsylate Powder.

Phenosulfanilamide is indicated for the prevention and treatment of surgical haemorrhage, thrombocytopenic purpura or anaphylactic purpura as well as haemorrhage due to other causes, such as cerebral haemorrhage, gastrointestinal haemorrhage, urinary tract haemorrhage, fundal haemorrhage, gingival haemorrhage, epistaxis, etc., and can be used in conjunction with other haemostatic drugs, such as aminomethylenic acid, vitamin K.

Production method of Etamsylate Powder.

It is obtained by the salt formation of diethylamine with sulfur dioxide and the addition of p-benzoquinone. Diethylamine, ethanol and water were added to the reaction pot, cooled to 0 ℃, and sulfur dioxide was passed until the pH of the reaction solution = 3.5-4, and the reaction temperature was controlled below 10 ℃ to obtain the diethylamine sulfite solution.

Then, slowly add p-benzoquinone at 0-10 ℃. After addition, the ethanol was recovered under reduced pressure, cooled and crystallised, filtered. Crystals plus distilled water heated to dissolve, with activated carbon decolourization and refining, that is, phenol sulfonyl ethylamine finished products.