Pharmaceutical Hydrochlorothiazide Raw Materials Powder CAS 58-93-5 API Factory Supply

CAS:58-93-5

MF: C7H8ClN3O4S2

MW: 297.74

EINECS:  200-403-3

Specification​: 99% min Hydrochlorothiazide 

Sample: Hydrochlorothiazide Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Hydrochlorothiazide Powder Usage and Synthesis.

Hydrochlorothiazide Powder, also known as dihydrochlorothiazide and dihydroketorolac, is a thiazide diuretic.Hydrochlorothiazide Raw Materials has a medium-acting diuretic effect. Hydrochlorothiazide CAS 58-93-5 is used as an antihypertensive agent in the treatment of mild to moderate hypertension. It has a mild and precise antihypertensive effect, decreasing systolic and diastolic blood pressure in standing and lying positions, and also increasing the antihypertensive effect of other antihypertensive drugs.

Uses and functions of Hydrochlorothiazide Powder.

White crystalline powder, odourless, slightly bitter taste. Insoluble in water or chloroform, soluble in acetone, slightly soluble in ethanol, soluble in sodium hydroxide solution, but easily hydrolysed.

• (1)Sodium excretion and diuretic effect: This product mainly inhibits the reabsorption of Na+ and Cl- in the anterior segment of distal tubule and proximal tubule (the effect is lighter), so as to increase the excretion of urinary sodium, potassium, chlorine, phosphorus and magnesium, and decrease the excretion of urinary calcium.
• 
• (2)Antihypertensive effect: It has mild and precise antihypertensive effect, it can reduce systolic and diastolic blood pressure in standing and lying position, and it can also increase the antihypertensive effect of other antihypertensive drugs.
• (3)Antidiuretic effect: This product can reduce the urine volume of nephrogenic uraemia, sometimes up to 50%, the specific mechanism of action is unknown.

Pharmacological Effects of Hydrochlorothiazide Powder.

• (1) Oedematous diseases: including congestive heart failure, cirrhosis with ascites, nephrotic syndrome, acute and chronic nephritis with oedema, early stage of chronic renal failure, sodium and water retention due to adrenocorticotropic hormone and oestrogen therapy.
• (2) Hypertension: it can be applied alone or in combination with other antihypertensive drugs, and is mainly used for the treatment of essential hypertension.
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• (3) Central or renal urolithiasis.
• (4)Nephrolithiasis: mainly used for the prevention of stones formed by calcium salts.

Production method of Galanthamine Powder.

This product is a typical representative of thiazide-type medium-acting diuretics, and ranked first in the United States in terms of drug sales in 1985. Because of its ease of administration, its moderate action and its applicability to all types of oedema.

Therefore, it is the most commonly used in clinical practice due to potassium excretion adverse reactions, the application of potassium salt supplementation is required.

Uses diuretic uses mainly inhibit the reabsorption of Na+ and Cl- in the proximal distal tubule, so that the renal excretion of sodium chloride increases and produces diuretic effect, is a kind of intermediate-acting diuretic.

This product has antihypertensive effect, and Li's medicinal patch, antihypertensive Shen Patch or Luo Bu Ma and other traditional Chinese medicines can enhance the effect of lowering blood pressure. It also has antidiuretic effect and can be used for the treatment of uremic syndrome.