Amitriptyline Hydrochloride Raw Material Amitriptyline HCL Powder

CAS: 549-18-8

MF: C20H24ClN

MW:313.86

EINECS: 208-964-6

Specification​: 99% min Amitriptyline Hydrochloride

Sample: Amitriptyline Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Amitriptyline Hydrochloride Raw Materials Usage and Synthesis

Manufactory Supply Amitriptyline HCL Raw Powder High Quality Amitriptyline Hydrochloride Raw Material , High Purity 99% Amitriptyline Hydrochloride Raw Powder CAS 549-18-8 Amitriptyline HCL Powder. Amitriptyline hydrochloride Powder is an antidepressant with antidepressant effects and strong sedative effects.

Uses and functions of Amitriptyline Hydrochloride Powder

1. Amitriptyline hydrochloride is an antidepressant with antidepressant effects and strong sedative effects. It is mainly used for endogenous exogenous depressive symptoms, menopausal depression, neurotic depression and depressive symptoms of organic psychosis, and also for enuresis in children and adolescents.
2. Amitriptyline Hydrochloride Raw Material UseThis product is an antidepressant with antidepressant effects and strong sedative effects.

1. Amitriptyline HCL Powder is mainly used for endogenous exogenous depressive symptoms, menopausal depression, neurotic depression and depressive symptoms of organic psychosis, also used for enuresis in children and adolescents.
2. Amitriptyline Hydrochloride Raw PowderUseAntidepressants for all types of depression and depressive symptoms of organic psychosisUseTricyclic antidepressants.

Pharmacological Effects of Amitriptyline Hydrochloride Raw Powder

Obtained from dibenzo[alpha,d]cycloheptadienone-(5) by addition, elimination and salt formation. Dried magnesium flakes and ether were put into a reaction tank and heated to reflux. The ether solution of dimethylaminochloropropane was added dropwise first, and then the ether solution of dibenzocycloheptadienone was added dropwise.

Reflow evaporate the ether, add toluene, cool and add saturated aqueous ammonium chloride solution. Stop stirring, separate the toluene solution, and then extract the aqueous layer with toluene for 5 times.

Production method of Raw Amitriptyline HCL Powder

Combine the toluene solution, wash with warm water 3 times, dry with anhydrous sodium sulfate, filter. The filtrate recovered toluene to get hydroxyamitriptyline crude product. After the crude product was refined by recrystallisation with toluene and activated carbon, it was dissolved in concentrated hydrochloric acid under stirring and heating, refluxed for 2-3 hours, and then the dilute hydrochloric acid was evaporated to dryness under reduced pressure.

Add isopropanol and activated carbon, heating and stirring reflux for 1 hour. Filter while hot, slowly cool the filtrate under stirring, crystallise, filter and dry to obtain amitriptyline hydrochloride. The yield is about 75%.