Vitamin additive Nicotinamide Powder

CAS:98-92-0

MF:C6H6N2O

MW:122.12

EINECS:202-713-4

Specification​: 99% min Nicotinamide Powder

Sample:Nicotinamide Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Off-White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Nicotinamide Powder Usage and Synthesis.

Nicotinamide and nicotinic acid are common in most acoustic combinations, and nicotinic acid also produces nicotinamide in animals. When the body is deficient in niacin and nicotinamide, pellagra can occur. They therefore prevent pellagra.

They play a role in the metabolism of proteins and sugars, which improves human and animal nutrition.

In addition to their use in medicine, they are also used in large quantities as food and feed additives. The production capacity of the world has more than 30,000 tonnes. In Japan, niacinamide is used in 40% of medicine and 50% of feed additives.

Food additives accounted for 10%.

Nicotinic acid and nicotinamide is non-toxic, in the natural medium mostly contained in animal liver, kidney, yeast and rice sugar, nicotinamide on the rat subcutaneous injection LD50 is 1.7 g / kg.

Uses of Nicotinamide.

Nicotinamide has better water solubility than niacin, but it is easy to generate complexes with vitamin C and caking. The dosage is 30-80mg/kg, which can be used in skin care products to prevent skin roughness, maintain skin cell health, and promote skin whitening. Used in hair care can promote scalp blood circulation, healthy hair follicles, promote hair growth and prevent baldness.

Biochemical research; Nutritional components of tissue culture medium; Clinical drugs for vitamin B family, used in the prevention and treatment of pellagra and stomatitis, lingual inflammation and other diseases.

Function of Nicotinamide.

1. Moisturising, oil control, reduce blackheads niacinamide can be very effective in reducing the loss of transdermal water, although the effect of single-use is not as good as hyaluronic acid and glycerin, but with the use of the effect of 1 +1 > 2; niacinamide can make the sebaceous glands in the state of "excitement" to calm down, and then to achieve the oil control, to reduce the effect of blackheads, acne.

2. good anti-wrinkle ability niacinamide's anti-wrinkle ability lies in the ability to activate ATP, providing keratinocyte vitality, increase collagen synthesis, and has a good synergy, can be used with other anti-wrinkle ingredients.

3. Very good auxiliary sunscreen effect UV rays bring harm to the human body is not only tanning, but also lead to the occurrence of immune suppression, and even skin cancer.

Many studies at home and abroad have shown that niacinamide can effectively reduce the occurrence of photo-immunosuppression of the skin during ultraviolet irradiation.

4. Good mildness compared to vitamin C, resorcinol derivatives and other ingredients, niacinamide mildness is not bad, many people's skin type can basically be used, but also still pay attention to the problem of skin tolerance, such as the Ordinary whitening serum 10% niacinamide concentration, or a certain degree of irritation.

So it is best to go through a skin tolerance test before use, to determine tolerance and then start using, and at the same time pay attention to not and acid-containing products, such as salicylic acid, fruit acids used together, to prevent too much skin irritation.

Production Method of Nicotinamide.

Nicotinic acid, boric acid and ammonia into the reaction pot, stirring through the ammonia, temperature dissolution; and then distillation recovery of ammonia, to 120 ~ C after moving to the dehydration pot to continue to concentrate; when the temperature reaches 145 ℃ began to add liquid ammonia, and continue to pass the ammonia reaction at 185 ~ 190 ℃ for 20 ~ 30h. Then reduce the temperature to 130 ℃, add distilled water dilution, add activated carbon, and pass the ammonia at 70 ~ 80 ~ C After the reaction, it was filtered while it was hot, and the filtrate was cold precipitated in water for 24h, separated and crystallised, and washed with ethanol and dried to obtain the finished product with a yield of 89%.