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Copper Gluconate Raw Materials Copper Gluconate Powder
Product Overview:
Copper gluconate is a light blue fine powder of copper.FAO/WHO Expert Committee on Food Additives (JECFA) evaluated copper gluconate as a copper supplement with "usefulness, safety and necessity". At present, the United States, Japan and other countries have set copper gluconate as a permitted food fortification agent, and as a copper deficiency treatment drugs.
Copper Gluconate Raw Materials Copper Gluconate Powder Attributes
CAS:527-09-3
MF:C12H22CuO14
MW:453.84
EINECS:208-408-2
Specification: 99% min Copper Gluconate Powder
Sample:Copper Gluconate Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: Light Blue to Blue
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Copper Gluconate Raw Materials Copper Gluconate Powder Details
Copper Gluconate Powder Usage and Synthesis.
Copper is a component of many important enzymes in the body, can promote the absorption and use of iron, can maintain the function of the central nervous system. Copper deficiency in the body of various blood vessels and bone brittleness increase, brain tissue atrophy, can also cause vitiligo and less white head and other melanin loss disease.
Uses and functions of Copper Gluconate.
Nutritional supplements. In Japan, copper fortification of milk replacer is permitted up to a maximum of 0.6 mg of copper per litre of standard milk-concentrated milk replacer.
Used as food additives, pharmaceutical raw materials.
Preparation of Copper Gluconate.
Fermentation method
Taking glucose as raw material, the black mould fermentation oxidation generates gluconic acid, and then reacts with copper carbonate (or alkaline copper carbonate) to generate copper gluconate, the production equipment of this method is huge, the concentration of energy consumption is high, and it is difficult to purify and crystallise.
Direct method
Copper gluconate is generated by direct reaction between calcium gluconate and copper sulphate. This method is simple, but the residual calcium sulfate is difficult to remove.
Chemical oxidation method
Take glucose as raw material, oxidise it to gluconic acid by ozone, concentrate and dehydrate it to get gluconolactone, and then react with copper carbonate to generate copper gluconate.
Acidification method
Add 1.2mol of calcium gluconate into equal moles of sulfuric acid solution, react at 60~90℃ for 1~2h, filter out the precipitated calcium sulfate precipitate while hot, and get colourless or light yellow gluconic acid solution (relative density 1.12~1.16). 4g of aqueous barium hydroxide and 1.5g of aqueous oxalic acid were added dropwise to the above gluconic acid solution, and the reaction was stirred for 15min, to remove the residual Ca2+ and S02-. The purified solution was then passed through anion and cation exchange resin to obtain a colourless and transparent gluconic acid solution.
Another 1 mol of crystalline copper sulfate solution was mixed with 2 mol of sodium hydroxide solution and reacted at 40-60°C for 0.5-1h, filtered, and the filter cake was washed with water to obtain black copper oxide crystals. Copper oxide crystals will be added to the gluconic acid solution in batches, reaction lh, filtration to remove unreacted material, cooling and standing 3 ~ 5h after precipitation of crystals. Add appropriate amount of 95% ethanol, stirred into a paste and filtered, the filter cake at 50 ℃ vacuum drying, finished products, yield 90% ~ 92.5%.
Product Method of Bulk Copper Gluconate Powder.
Crystallised from the reaction of gluconic acid with copper oxide.
Crystallised from the reaction between gluconate and copper salt.
It is crystallised by the reaction between sodium gluconate and copper sulphate.
Obtained by electrolytic oxidation of glucose to gluconic acid and neutralisation with copper carbonate, while sorbitol is generated.