98% purity Piperine Powder Pure Piper Nigrum Extract

Raw Materials Piperine Powder

CAS:94-62-2

MF:C17H19NO3

MW:285.34

EINECS:202-348-0

Specification: 99% min Piperine Powder

Sample:Piperine Powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Ausreson

Appearance: White powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Piperine Powder Usage and Synthesis.Extracto Estándar de Pimienta Negra: Polvo de Piperina con 98% de Pureza

Piperine is a broad-spectrum anticonvulsant, with good antagonistic effects on experimental electroconvulsions in mice, and with varying degrees of antagonistic effects on convulsive seizures and audiogenic seizures induced by pentylenetetrazol, indohexadine toxin, strychnine, and intracerebroventricular injections of cylinder arrow toxins, glutamate, and so on.

Clinical trials have also shown efficacy in certain types of epilepsy. There is a folk recipe for epilepsy "white pepper and radish", and a simplified structure of piperine analogue 3-(3,4-dimethyl-dioxyphenyl)acryloylpiperidine (trade name anti-epileptic) was artificially synthesised. Piperine is more toxic to flies than pyrethrum.Extrait Standardisé de Poivre Noir : Poudre de Pipérine titrée à 98%

Characteristic of Piperine.Standardisierter Pfefferextrakt: Piperin-Pulver mit 98% Reinheit

An alkaloid with the molecular formula C17H19NO3.Стандартизированный экстракт черного перца: порошок пиперина 98% чистоты

It exists in a variety of pepper plant fruits, for its pungent flavour component, but the pungent taste of pepper mainly from its isomer Jiamicine. In the commercial black pepper and white pepper, piperine content of 5% to 9%, sometimes up to 11%.Extrato Padronizado de Pimenta-Preta: Pó de Piperina com 98% de Pureza

Piperine is colourless monoclinic prismatic crystals; melting point 130-133 ℃; soluble in acetic acid, benzene, ethanol and chloroform, slightly soluble in ether, almost insoluble in water and petroleum ether; the entrance is initially tasteless, after a pungent taste; can be generated with a strong acid crystalline salt.

The Core Scientific Mechanism of Piperine Powder in Enhancing Metabolism

1. Inhibiting ‘Piperine-4-Hydroxylase’ to Prolong the Half-Life of Metabolically Active Substances

• Piperine powerfully inhibits the activity of the CYP3A4 enzyme (studies indicate an inhibition rate exceeding 60%), thereby extending the ‘half-life’ (i.e., duration of action) of the aforementioned metabolically active substances in the bloodstream. For instance:
• When taken with curcumin, piperine increases curcumin's bioavailability by 2000%. Curcumin itself promotes fat cell breakdown and reduces inflammation-related metabolic disorders.
• When taken with caffeine, it prolongs caffeine's effects of stimulating the sympathetic nervous system and elevating basal metabolic rate (BMR), enabling the body to sustain higher energy expenditure over an extended period.

2. Activates ‘thermogenesis’ to directly expend calories

• Stimulates brown adipose tissue (BAT): Human fat comprises white adipose tissue (storing energy) and brown adipose tissue (burning energy to generate heat). Piperine activates ‘uncoupling protein 1 (UCP1)’ in brown fat, promoting the combustion of glucose and fatty acids within BAT. This releases energy as heat (rather than storing it as fat), thereby directly elevating metabolic rate.
• Enhance the Thermic Effect of Food (TEF): After eating, the body expends energy digesting and absorbing food (TEF). Piperine slightly increases the TEF of protein, carbohydrate, and fat intake.

3.Regulate adipocyte function, reducing fat storage

• Inhibits lipogenesis: By downregulating the activity of ‘key lipogenic enzymes’ (such as fatty acid synthase FAS and lipoprotein lipase LPL), it reduces the conversion of preadipocytes into mature adipocytes, curbing fat accumulation at its source.
• Promoting lipolysis: Activates ‘lipolytic enzymes’ (such as hormone-sensitive lipase, HSL), prompting fat cells to release stored fatty acids. These fatty acids subsequently enter the bloodstream to be ‘burned’ by muscle cells for energy, reducing fat accumulation.

4. Enhancing insulin sensitivity to indirectly stabilise metabolism

• - Reducing hepatic gluconeogenesis (conversion of non-carbohydrates into glucose) to minimise blood glucose fluctuations;
• - Promoting glucose uptake and utilisation by muscle cells, thereby alleviating insulin secretion pressure. This improves insulin signalling pathways, preventing metabolic rate decline and fat accumulation caused by insulin resistance.

Pharmacological Effect of Piperine.

Pepper is the most essential ingredient in Indian medicine and is used for the treatment of a wide range of ailments.

Pharmacological studies have demonstrated many of their traditional medicinal properties such as analgesic and antipyretic effects, antioxidant action, antimicrobial action etc. Piperine is the active ingredient of pepper.

Piperine has a wide range of pharmacological effects and has been found to have antioxidant, immunomodulatory and antitumour effects.

FAQ.

Q: Is piperine safe? Are there any side effects?

A: At recommended doses (typically 5-20 milligrams daily), piperine is safe for the vast majority of people. However, as it may affect drug-metabolising enzymes, individuals taking prescription medications (such as antihypertensives, anticoagulants, or antiepileptics) must consult their doctor before using piperine-containing supplements. This must be clearly stated by the manufacturer on the product label.

Q: What distinguishes piperine from BioPerine®?

A: BioPerine® is a proprietary piperine extract supported by relevant clinical research. Our Piperine Powder is a generic, high-purity piperine offering the same core active ingredient as BioPerine® but at a more cost-effective price point, providing brands with an alternative high-quality option.

Q: When should piperine be added to formulations?

A: Piperine should be taken alongside the core active ingredient whose absorption you wish to enhance. Therefore, during formulation, ensure both are present in the same dosage form (e.g., within the same capsule or powder serving).

Q: What are the minimum order quantities (MOQ) and sample policies?

A: Our standard MOQ is 1 kilogram. We offer paid samples of 100 grams for promising collaborative projects to support your formulation development and testing.

Our Strengths

Henrikang possesses the capability to manufacture any capsule formulation. From sourcing every ingredient in the formula to post-filling inspection, we undertake the entire process at the most competitive pricing and with the swiftest delivery times.

With extensive experience, we can assist you in developing new products for your target audience or discuss how to scale up production efficiently. As your partner, we are committed to achieving long-term success in capsule manufacturing.

As a leading Chinese OEM manufacturer for nutritional supplement ingredients and branded products, we hold certifications including ISO 22000, ISO 9001, HACCP, GMP, Halal, CE, CE-ROHS, Kosher, SGS, Intertek, Eurofins, and GMP. Our facility has successfully undergone US FDA inspection and registration.