Raw Materials Ginkgo Biloba Leaf Extract powder

CAS:90045-36-6

MF:/

MW:/

EINECS:289-896-4

Specification: 99% min Ginkgo Biloba Leaf Extract Powder

Sample:Ginkgo Biloba Leaf Extract Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ginkgo Biloba Leaf Extract Powder Usage and Synthesis.

Ginkgo biloba extract can also promote the brain circulation metabolism, improve memory function, improve by NaNO2-induced deficits in memory impairment in addition to its anti-hypoxia effect may be related to its increase in cerebral blood flow and improve hypoxia.

Ginkgo biloba extract injection is a product for the treatment of deafness, tinnitus, vertigo and other blood circulation and nerve disorders, and has been included in the National Health Insurance Catalogue. Infusion therapy is usually given as 2-4 capsules once or twice a day, and the dose can be adjusted to 5 capsules twice a day if necessary.

Follow-up treatment can be oral ginkgo biloba extract tablets or drops, or as directed by a physician.

Uses of Ginkgo Biloba Leaf Extract.

1. Acute and chronic cerebral insufficiency and its sequelae: stroke, inattention, memory loss, dementia.

2, ear blood flow and nerve disorders: tinnitus, vertigo, hearing loss, ear labyrinth syndrome.

3, eye blood flow and nerve disorders: retinopathy and nerve disorders caused by diabetes, age-related macular degeneration, blurred vision, chronic glaucoma.

4, peripheral circulatory disorders: various arterial occlusive disease, intermittent claudication, paralysis and cold hands and feet, limb pain.

Drug interactions of Ginkgo Biloba Leaf Extract.

Ginkgo biloba extract is a commonly used drug in the treatment of cardiovascular diseases, often combined with antiplatelet, sedative, antihypertensive and lipid-lowering drugs.

Ginkgo and its monomer components quercetin, kaempferol and isorhamnetin and other flavonoids have inhibitory effect on CYP3A4, CYP2C9, CYP2B6, etc., and its monomer components ginkgolides A, B and bilobalide and other lactones have inducing effect on CYP1A2, CYP2B1/2, CYP3A2, CYP2C19, UGT1A1, etc., and are P -glycoprotein substrate, and drug co-use is easy to trigger drug interactions, and the role of the complex, so need to attract extensive attention.

In recent years, there have been reports of individual cases of bleeding caused by taking ginkgo biloba preparations or combining with other anticoagulant drugs.

Ginkgo biloba extract inhibits PAF and causes bleeding, of which ginkgolide B is considered to be the most important component in inhibiting PAF. However, there are no corresponding controlled studies. Currently commercially available ginkgo biloba products vary widely in composition and amount.

The dose as well as the exact amount of ginkgolide B associated with bleeding is still unknown. Moreover, there may be other ingredients in the products that are capable of causing bleeding. Therefore, further research in this area is needed.

Therefore, based on the results of the current study, cases of bleeding caused by Ginkgo biloba extract preparations should be communicated to physicians to draw sufficient attention.

And try to avoid ginkgo biloba extract preparations with anticoagulant drugs such as aspirin and warfarin.

Pharmacological effect of Bulk Ginkgo Biloba Leaf Extract Powder.

1、Antagonism of PAF: Competitively bind to the membrane receptor of PAF and antagonise the action of PAF, thus inhibiting platelet aggregation, endothelial cell permeability, bronchial smooth muscle contraction and inflammatory response.

2、Scavenging effect of free radicals: It can remove excessive free radicals in the organism and inhibit lipid peroxidation of cell membrane, thus protecting the cell membrane and preventing a series of injuries caused by free radicals to the organism, such as thrombosis, inflammation and atherosclerosis.

3、Adjustment effect on circulatory system: By stimulating the release of catecholamines and inhibiting their degradation, as well as by stimulating the generation of prostacyclin and endothelial diastolic factor to produce arterial diastolic effect, together to maintain arterial and venous vascular tone.

4、Haemodynamic improvement effect: It has the effect of reducing the viscosity of whole blood, enhancing the plasticity of red blood cells and white blood cells, and improving blood circulation.

5、Tissue protection effect: increase the supply of oxygen and glucose to ischemic tissues, increase the number of brain muscarinic receptors and the renewal of norepinephrine, as well as enhance the function of certain central cholinergic system.