Raw Materials Naringin Dihydrochalcone Powder

CAS:18916-17-1

MF:C27H34O14

MW:582.56

EINECS:700-320-7

Specification: 99% min Naringin Dihydrochalcone

Sample:Naringin Dihydrochalcone Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Naringin Dihydrochalcone Powder Usage and Synthesis.

Naringin is a kind of natural cheap flavanone glucoside, which can be extracted from the peel of citrus fruits, especially the peel of grape sleeve. The content of naringin in pomelo peel is about

one, and the pomelo peel accounts for more than the mass of the whole cypress, and China is a big country producing pomelo peel, so the synthesis of dihydrochalcone using naringin has a

broad prospect.

Uses of Naringin Dihydrochalcone.

Application in Pharmaceutical Industry: Dihydrochalcone compounds have various physiological and pharmacological activities, and through the study of their constitutive relationship and their

modification, new drugs with important value can be developed.

It has been found that dihydrochalcone compounds are useful in the treatment of diabetes mellitus.

In addition, dihydrochalcone compounds have an antioxidant pharmacophore, 2,6 dihydroxyacetophenone structure, through the elimination of peroxides, scavenging hydroxyl radicals.

Applications in the food industry: Dihydrochalcones are one of the most interesting and mature natural sweeteners.

According to research, the aromatic family of citrus fruit and peel contains dihydroflavonoids,which itself is not sweet, but in the appropriate conditions into dihydrochalcone glycosides, it can be sweet, and its sweetness is higher than saccharin, sweeteners or aspartame and other commonly used sweeteners, usually equivalent to the sweetness of sucrose 100-1000 times,saccharin 3-5 times.

Dihydrochalcone sweeteners have a refreshing taste, a long-lasting aftertaste, and an excellent shielding effect against wilting, and dihydrochalcone is now widely used in the food industry as a

sweetener or flavour enhancer.

Individually When used alone as an artificial sweetener, its added concentration is 15-20mg, and when used in combination with other sweeteners, especially with saccharin, it can produce

excellent synergistic effect.

In addition, dihydrochalcone sweeteners can be used in alcoholic and non-alcoholic beverages,hors d'oeuvres, tomato sauce and mayonnaise.

Synthetics of Naringin Dihydrochalcone.

Naringin dihydrochalcone was synthesised from naringin as raw material: the sweetness of naringin dihydrochalcone is 100 times that of sucrose, and its structural formula has R as

hydrocarbon group, R' as hydrogen, and R'' as neotangerine peel sugar group.The sweetness of naringin dihydrochalcone is relatively low because the number of methoxy and hydrocarbon groups on the ring directly affects the degree of sweetness of the compound.

Naringin is first treated with alkali, the concentration of alkali is generally 10 per cent to 25 per cent. In order to ensure that all of the raw materials in the base can be neutralised by alkali, alkali

and flavanone molar ratio of 3 to 4, U.S. Patent 2700047, a more detailed report on the amount of flavanone and alkali on the chalcone ring-opening effect, and pointed out that the alkali and

flavanone molar ratio of flavanone to when the flavanone can be completely converted to chalcone.

Product Method of Bulk Naringin Dihydrochalcone Powder.

There are many types of dihydrochalcone, and the naringin dihydrochalcone is used as an example to illustrate the method of preparation.

Grapefruit peel is thoroughly mixed with a small amount of 50% cold methanol solution and filtered, and the filtrate is left in a refrigerator for several days to allow complete crystallisation.

The crystals were then dissolved in water for recrystallisation. The naringin crystals obtained from recrystallisation were dissolved in 10% cold potassium hydroxide solution and 105 of palladium

carbon hydrogenation catalyst was added and shaken continuously at room temperature and 207 KPa hydrogen pressure until the hydrogenation reaction stopped.

The catalyst was filtered off and the filtrate was placed in a water bath, acidified with concentrated hydrochloric acid and then placed in a refrigerator to allow complete crystallisation.

Naringin dihydrochalcone crystals were collected, washed with water and then recrystallised in water, filtered and dried under vacuum to give crystals (melting point 170°C). If recrystallised

again in acetone, crystals of another crystalline form are obtained (melting point 212°C).