Arachidonic acid Raw Materials Arachidonic acid powder

CAS:506-32-1

MF:C20H32O2

MW:304.47

EINECS:208-033-4

Specification: 99% min Arachidonic acid powder

Sample:Arachidonic acid powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Arachidonic acid powder Usage and Synthesis.

1.Regulate cardiac excitabilityRecently, it has been reported that arachidonic acid and its metabolites such as LTC4 can activate the toxic causoline-like K+ channel coupled with G protein in a receptor-independent manner, and regulate cardiac excitability under physiological and pathological conditions.

2.Participate in neuroendocrine secretionArachidonic acid can stimulate the secretion of anterior pituitary, placenta and mast cells, and participate in the regulation of the secretion of many hormones and neuropeptides in various neuroendocrine tissues, such as oxytocin, pressin, insulin and glucagon.

3. Promote cell division of arachidonic acid and its metabolites have the effect of promoting cell division, and its metabolites have this effect in smooth muscle cells, fibroblasts and lymphocytes.

4.Inhibition of platelet aggregation arachidonic acid and its metabolites can cause vasodilation. Vascular endothelial cells are closely related to arachidonic acid enzyme, which can release vasodilatory factors, relax vascular smooth muscle and dilate blood vessels under certain stimuli.

Due to the above physiological functions, arachidonic acid is widely used in cosmetics, medicine and food.

Uses of Arachidonic acid powder.

Nutritional additive. Stabilising, anti-peptic ulcer and gastrointestinal dysfunction, acts on the uterus. Peanut tetraenoic acid is an important substance for the development of human brain and optic nerve, and plays an important role in improving intelligence and enhancing visual acuity.

Arachidonic acid has a series of physiological activities such as esterification of cholesterol, increasing the elasticity of blood vessels, lowering blood viscosity and regulating the function of blood cells. Peanut tetraenoic acid has important effects on the prevention of cardiovascular disease, diabetes and tumours.

Characteristic of Arachidonic acid powder.

AA is found in certain mosses, seaweeds and other plants, as well as in the adrenal glands and liver of pigs and cattle and in herring. It is catalysed by different enzyme systems in living organisms to produce important active substances such as prostaglandins, thromboxanes and leukotrienes.

There are four double bonds in the molecule, the first of which starts on the 6th carbon atom from the methyl end, belonging to ω-6 type unsaturated fatty acids.AA is a light yellow oily liquid. Soluble in ethanol, acetone, benzene and other organic solvents. mp about 49 ° C; bp169-171 ° C / 19.998Pa; flash point greater than 110 ° C; refractive index of 1.4824; density of 0.922g/ml; iodine value of 333.4.

There are four active hypomethyl groups in the molecule, it is easy to generate free radicals with oxygen. In 21% KOH ethylene glycol, the UV absorption spectrum of isomerisation at 180℃ for 15min, there are characteristic absorption peaks at 233nm, 268nm, 315nm, 346nm.

Product Method of Bulk Arachidonic acid powder.

Urea inclusion method

Preparation of mixed fatty acid ether solution take pig adrenal homogenate, add 95% ethanol (3 times the amount, 2 times the amount) extraction 2 times, filtration, filtrate, get filtrate, concentrate to remove ethanol, add ether extraction, concentrate to remove the ether, to get the lipoid.

Add 1.5 times ethanol to dissolve, add 500g/L potassium hydroxide to adjust pH10 or above, reflux with nitrogen to get mixed fatty acid potassium salt. Add acid to adjust pH3, add ether extraction, get mixed fatty acid ether solution.

Porcine adrenal homogenate [ethanol, ether] → [KOH, HCl, pH10, pH3] mixed fatty acid ether solution mixed unsaturated fatty acid preparation take mixed fatty acid ether solution, concentrate to remove the ether, add 10 times the amount of acetone to dissolve, in turn, at -5 ℃, -25 ℃, -45 ℃, -72 ℃ cryocrystallisation, each time 2h, filtration, filtrate concentrate to remove acetone, get mixed unsaturated fatty acids.

Mixed fatty acid ether solution [acetone, 2h] → [-5 ℃, -25 ℃, -45 ℃, -72 ℃] mixed unsaturated fatty acids arachidonic acid finished product preparation will be mixed unsaturated fatty acids with the appropriate amount of methanol to dissolve, add urea and methanol, to be dissolved in urea, in order at -3 ℃, -20 ℃, -75 ℃ cryocrystallisation, filtration, filtrate with anhydrous sodium sulphate drying, evaporate the methanol, to get the arachidonic acid Finished product.

Mixed unsaturated fatty acids [urea, methanol, anhydrous sodium sulfate] → [-3 ℃, -20 ℃, -75 ℃] arachidonic acid finished product