Raw Materials Ginkgo Leaf Extract Powder

CAS:90045-36-6

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EINECS:289-896-4

Specification: 99% min Ginkgo Leaf Extract Powder

Sample:Ginkgo Leaf Extract Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ginkgo Leaf Extract Powder Usage and Synthesis.

Ginkgo biloba extract is a natural herbal medicine extracted from the leaves of the ginkgo tree and has a variety of pharmacological effects.

It inhibits the activity of angiotensin converting enzyme, dilates blood vessels and increases blood flow, thus acting to lower blood pressure and improve microcirculation.

In addition, Ginkgo biloba extract inhibits platelet activating factor and cyclooxygenase or lipoxygenase, antagonising platelet aggregation and preventing thrombosis. For the central nervous system, Ginkgo biloba extract is able to improve memory function, promote circulatory metabolism in the brain, and inhibit inflammation and allergic reactions.

Currently, CFDA has approved dozens of ginkgo biloba extract dosage forms, which can be applied to the prevention and care of cardiovascular, cerebrovascular, neurological and other systemic diseases.

The main component of Ginkgo biloba extract is ginkgo flavonoid glycosides, which can dilate cerebral blood vessels, promote cerebral blood circulation, increase cerebral blood flow, improve and protect brain cells.

Uses of Ginkgo Leaf Extract.

Ginkgo biloba extract is extracted from the leaves of the ginkgo tree and has a variety of medicinal values and health benefits.

Among them, it has a strong antioxidant effect, which can scavenge excess free radicals in the body, inhibit lipid peroxidation of cell membranes, protect cell membranes, and prevent a series of damages caused by free radicals to the organism.

In addition, Ginkgo biloba extract can regulate the function of the circulatory system, stimulate the release and inhibit the degradation of catecholamines, stimulate the production of prostacyclin and endothelial diastolic factor, maintain the tone of arterial and venous blood vessels, and improve haemodynamics.

In the nervous system, Ginkgo biloba extract increases cerebral blood flow, enhances platelet-activating factor antagonism, and treats vascular aging, inadequate cerebrovascular blood supply, and other neurological disorders. In addition, Ginkgo biloba extract can also improve immunity and delay aging.

Therefore, Ginkgo biloba extract is widely used in the prevention and treatment of cardiovascular, cerebrovascular, neurological and other systemic diseases.

Pharmacological Effect of Ginkgo Leaf Extract.

1.Effects on digestive system

Ginkgo biloba extract can significantly improve PAF and endotoxin-induced gastric and intestinal ulcers in rats, and can partially inhibit the damage of ethanol on the stomach. It has potential therapeutic effects on hepatic cirrhosis. Ginkgo terpene lactone B may have a role in the treatment of acute pancreatitis.

2. Effects on respiratory system

The ethanol extract of Ginkgo biloba has a direct relaxant effect on tracheal smooth muscle. Inhalation of aerosolised Ginkgo biloba extract not only inhibited bronchoconstrictor effect, but also suppressed PAF-induced leucopenia and eosinophilia. Ginkgo biloba extract is of great significance in the suppression and treatment of bronchial hyperresponsiveness.

3.Anti-aging effect

Ginkgo biflavones, isoginkgo biflavones, ginkgetin and quercetin in Ginkgo biloba have inhibited lipid peroxidation, especially quercetin has stronger inhibitory activity.

4.Role in transplant rejection and other immune reactions

Ginkgo biloba extract can prolong the survival time of transplanted skin, ectopic heart xenografts, orthotopic liver xenografts. Ginkgo biloba extract can inhibit the body's natural killer cell activity against KC526 target cells, and also block the natural killer cell activity caused by interferon.

5.Anti-tumour effect

Ginkgo biloba green leaf crude extract that is fat-soluble part can inhibit the EB virus, seventeen carbene salicylic acid, white fruit flavin (Bilo-betin) have strong inhibitory activity; Ginkgo biloba total flavonoids can increase the weight of the thymus of the tumor-bearing mice and the level of SOD activity, mobilising the body's intrinsic anti-tumor ability; quercetin and poplar plum flavin can inhibit the occurrence of carcinogens.

6.Antioxidant effect

Ginkgo biloba extract can directly scavenge lipid free radicals, lipid peroxidation radicals and alkyl radicals, etc., and terminate the chain reaction chain of free radicals. It can also participate in regulating and improving the activity of antioxidant enzymes such as peroxide dismutase, glutathione peroxidase and other antioxidant enzymes.

The antioxidant effect of flavonoids in EGB even exceeds that of vitamins and has anti-free radical attack properties in vitro.

Extraction method of  Bulk Ginkgo Leaf Extract Powder.

1. Ethanol extraction - large pore resin adsorption separation method to pick out impurities and mouldy leaves, washed, chopped, with 70% ethanol reflux extraction, extract, filtered, decompression recovery of ethanol, high-speed centrifugation to slag, add appropriate amount of pure water dilution, added to the large pore adsorbent resin column, water elution until the eluate is clear and bright light, and then eluted with a certain concentration of ethanol, the collection of the eluate, concentration under reduced pressure, vacuum drying that is obtained.

2. Acetone extraction - lead hydroxide precipitation method ginkgo biloba extracted with 60% acetone, cooled and filtered, extracted with carbon tetrachloride, add butanone and mixing, separation and precipitation of acetone - butanone phase, in the ketone phase and then add a solid ammonia sulfate stirring, filtration of solid substances, evaporation filtrate under reduced pressure to a concentration of 20% -60% of the solids, diluted to a concentration of 50% denatured ethanol to a concentration of 10% of the solids. Add a suspension of lead hydroxide and filter off the precipitate.

Concentrate the filtrate to half volume under reduced pressure, then add ammonia sulphate and butanone to the concentrate under stirring, and precipitate the butanone-ethanol phase at the end of stirring; separate the butanone-ethanol phase from the aqueous phase, and then add butanone to the aqueous phase, stirring, and precipitate the butanone-ethanol phase, which is combined in the above butanone-ethanol phase.

Add ammonia sulphate under stirring, mix and separate the precipitated aqueous phase, dry the butanone-ethanol phase with sodium sulphate, evaporate to dryness under reduced pressure, dissolve the denatured viscous residual liquid with denatured ethanol, leave for 12 hours to separate the precipitate precipitated, evaporate under reduced pressure, and dry in vacuum to obtain.