Ethyl acetoacetate Liquid CAS 141-97-9

CAS:141-97-9

MF:C6H10O3

MW:130.14

EINECS:205-516-1

Specification​: 99% min Ethyl acetoacetate Powder

Sample:Ethyl acetoacetate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Colorless

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ethyl acetoacetate Powder Usage and Synthesis.

Ethyl acetoacetate is an important organic synthesis intermediate with ketone and enol properties and is chemically very active.

It can be used to synthesize a variety of heterocyclic compounds, such as pyridine, pyrrole,pyrazolone, pyrimidine, purine and cyclic lactone, and is widely used in drug synthesis.

For example, ethyl acetoacetate and resorcinol cyclization to get 4-methyl-7-hydroxy coumarin, is an anti-allergy drug scale intermediate; and benzyl chloride condensation to get α-acetyl phenylpropionic acid ethyl ester, is a cough medicine cough ketone intermediate;and benzoyl chloride condensation to get benzoylacetic acid ethyl ester, is a central excitatory drug stalkerine hydrochloride intermediates; and thiourea ring with the preparation of the antithyroid drug methylthiocytosine, is a coronary artery It is the intermediate of the coronary artery dilator Pansentin.

Uses of Ethyl acetoacetate.

Ethyl acetoacetate is an important raw material for organic synthesis, which is used in pesticide production to synthesize the intermediate α-chloroethyl acetoacetate of the organophosphorus insecticide Flytoxin Phosphorus, the intermediate of Pyrimidophos 2-methoxy-4-methyl-6-hydroxypyrimidines, the intermediate of Diazinon Phosphorus 2-isopropyl-4-methyl-6-hydroxypyrimidines, as well as the carbamates of the insecticide Anti Aphidic Vibrio, the fungicide Oxamylin, the herbicide Flavoprene, and also the new varieties of fungicide Cyprodinil, Fluoropyrimidines (cyprodinil), Rodenticide, Rodenticide, and so on.

Nicotinic acid, rodenticide rodenticide ether, rodenticide, etc., but also a new variety of fungicide pyrimethanil (cyprodinil), fluopyrimidines (difulmetorim), furoxypyrin (furammetpyr) and plant growth regulator androstenol (cintofen) intermediates, in addition, ethyl acetoacetate is also widely used in pharmaceuticals, plastics, dyes, spices, varnish and additives and other industries. In addition, ethyl acetoacetate is also widely used in medicine,plastics, dyes, spices, varnishes and additives.

Occasionally used in cosmetic flavor such as gardenia, can give the wine fruity fragrance or floating non-floral head fragrance. In the toilet water or water agent class can give ethanol to round mature feeling.

Widely used in edible flavor, can be used in many fruit or wine flavor, such as apple, apricot,peach, cherry, berry and yellow wine, brandy, white wine, whiskey, rum and other edible flavor and wine flavor.

Content analysis of Ethyl acetoacetate.

Method 1: Accurately weigh about 0.8 g of the sample and determine it by method 2 of the method for determination of aldehyde and ketone content (OT-7). The maintenance time was 15 min.

Equivalence factor (e) in the calculation was taken as 65.07. Method II 50 ml of freshly distilled pyridine was taken into a 250 ml conical flask and about 450 mg of accurately weighed specimen was added.

Cover the pendant and swirl and shake until complete dissolution. Add a few drops of thymol test solution (TS-248) with 0.1 mol / L sodium methanol pyridine solution titration until the beginning of the blue water endpoint. Titration will be nitrogen flow through a 6mm glass tube sent to the A bottle, the short glass tube should be installed near the lower end of the buret.

A blank test is carried out as above in the same li. Per Ml0.1mol/L sodium methanol pyridine liquid phases in ethyl acetoacetate (C6H10O3) 13.01mg. method three according to GT-10-4 in the determination of non-polar column method.

Product Method of Bulk Ethyl acetoacetate Powder.

The preparation method commonly used in the industry is the esterification of bis-vinyl ketone and anhydrous ethanol catalyzed by concentrated sulfuric acid, to get the crude ethyl acetoacetate, and then distilled under reduced pressure to get the finished product.In the esterification pot according to the proportion of ethanol and sulfuric acid, stirring and heating, when the temperature rises to 82 ℃, start adding bis-vinyl ketone drops,esterification temperature shall not exceed 130 ℃.

Continue to reflux until the reaction temperature no longer changes and the esterified liquid without bis-vinyl ketone when the end of the reaction. The material temperature down to 120 ℃ or less, in the control of reflux ratio of 1:1 conditions to remove low-boiling material, when the low-boiling material is no longer distilled, increase the vacuum to 86.6 kPa, continue to remove low-boiling material, when the tower top temperature rises to 100 ℃ or more, and then increase the vacuum to 97.3 kPa, distilled from the finished product, the content of more than 97%. Also available ethyl acetate self-condensation reaction. 2CH3COOC3H5 [Na] →

CH3COCH2COOC2H5 will be 250g of sodium metal added to 4240mL ethyl acetate, the beginning of the reaction is very slow, need to be warmed up on a water bath, once the reaction begins to be very violent, need to be cooled. The ethyl acetate was recovered by distillation after refluxing the reaction.

Add 1375mL of 56% acetic acid solution and stir to reflux, add 250g of table salt, separate out the oily material, extract with ether, recover the ether from the extract, and wash with 10% sodium bicarbonate solution until it is acid-free. After drying with calcium chloride,

distillation under reduced pressure, collect 76 ~ 78 ℃ / 2.4kPa fraction is the finished product,yield close to 30%.