Gaba Raw Materials Powder CAS 56-12-2

CAS:56-12-2

MF:C4H9NO2

MW:103.12

EINECS:200-258-6

Specification: 99% min Gaba Powder

Sample:Gaba Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Gaba Powder Usage and Synthesis.

As an inhibitory neurotransmitter, γ-aminobutyric acid has the effect of waking up the brain, it can improve the cerebral blood flow circulation, increase the supply of oxygen, and promote the metabolic function of the brain, it can be used for the treatment of headache, tinnitus, and impaired consciousness arising from stroke, after-effects of head trauma and after-effects of cerebral vascular sclerosis, etc., and it also has a certain effect on the improvement of the function of the liver and kidneys. It can have antihypertensive effect, it can promote cerebral blood flow to increase the supply of oxygen, promote brain metabolism.

In addition to act on the cerebrovascular center of drinking water, so that the blood pressure drops, while inhibiting the secretion of antidiuretic hormone, dilate blood vessels, reduce blood pressure.

It can also treat epilepsy because it is an inhibitory amino acid that counteracts the excitatory effect of glutamate, thus treating epilepsy.

It can also improve lipid metabolism and prevent atherosclerosis, while it also has a sobering effect, contributing to the excretion of alcohol metabolites, thus sobering effect.

It can prevent skin aging, as well as have the function of eliminating body odor, at the same time, it also has to enhance the flavor, has a similar glutamate sweetness, can enhance the flavor of food, mainly these effects and functions.

Uses of Gaba.

4-Aminobutyric acid has the effect of lowering blood lipids and is suitable for the treatment and prevention of various types of hepatic coma. It can be used in the treatment of poliomyelitis, cerebral hemorrhage, and as an antidote for gas poisoning. Also used in biochemical research and organic synthesis.

It can reduce blood ammonia and promote brain metabolism. Used in the treatment of various types of hepatic coma, also used in post-stroke sequelae, cerebral arteriosclerosis, head trauma sequelae and uremia, gas poisoning and other coma caused by.

Pharmacological effect of Gaba.

Gamma-aminobutyric acid is a strong neuroinhibitory amino acid, with sedative, hypnotic, anticonvulsant and hypotensive physiological effects. 

It is InhibitoryNeurotransmitter, which can inhibit the activity of animals and reduce energy consumption.

Aminobutyric acid acts on γ-aminobutyric acid receptor in animal cells, γ-aminobutyric acid receptor is a chloride ion channel, the inhibitory or excitatory property of γ-aminobutyric acid is dependent on the concentration of chloride ions inside and outside of the cell membrane, γ-aminobutyric acid receptor activation leads to the opening of the chloride ion channel, which can increase the permeability of the cell membrane to chloride ions, so that the chloride ions flow into the neuronal cells, causing hyperpolarization of the cell membrane, inhibiting the neuronal cell element agitation, thus reducing the animal's locomotion.

Product Method of Bulk Gaba Powder.

There are synthetic method and fermentation method.

1. Synthetic method is produced by pyrrolidone ring-opening. Lime digested into lime milk with distilled water, pumped into the hydrolysis reactor, add pyrrolidone, heating to 125-130 ℃, the reaction pressure is maintained at 0.29MPa, insulation reaction more than 10-14h.

After the end of the reaction, cool down to 30 ℃ discharge filtration, washed with distilled water. Filtrate with ammonium bicarbonate until no calcium ions detected, and then add activated carbon at 80 ℃ insulation decolorization 30min, 60 ℃ filtration, washed with distilled water, washings and filtrates combined, at 60 ℃ concentration under reduced pressure to precipitation of crystals, add ethanol, cooling, filtration, drying, to get the finished product, the yield is 85% or more.

2. Fermentation method using Escherichia coli as the strain. Fermentation medium is bran hydrolysate, corn syrup, peptone, magnesium sulfate and sodium chloride. Soybean oil is used as defoamer, the dosage is about 0.1%, and the fermentation unit is about 100 enzyme units/ml fermentation solution.

In the extraction process, using the role of Escherichia coli decarboxylase, L-glutamic acid is converted into γ-ammonia tyrosine in aqueous solution can be dissociated into a cation of the characteristics of the strong acidic styrene-based cation exchange resin for ion exchange, ammonia elution, extraction, and then resin purification, concentration, crystallization, drying and then the finished product.