manufacturers L-Hydroxyproline Raw Powder cas 51-35-4 supplier

CAS:51-35-4

MF:C5H9NO3

MW:131.13

EINECS:200-091-9

Specification: 99% min L-Hydroxyproline Powder

Sample:L-Hydroxyproline Powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White powder

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

About us

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L-Hydroxyproline Powder Usage and Synthesis.

L-hydroxyproline is a natural component of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylases were identified and these enzymes were used in the industrial production of trans-4- and cis-3-hydroxy-L-proline.

L-hydroxyproline is an important amino acid that has a variety of applications in living organisms. In collagen, the amount of L-hydroxyproline is a criterion for determining its quality.

In addition, L-hydroxyproline is used in the synthesis of various compounds such as cyclic (L-leucine-trans-4-hydroxy-L-proline) 3-isobutyl-8-hydroxyhexahydropyrrolo[1,2-A]pyrazine-1,4-dione.L-Hydroxyproline is also commonly used in the treatment of hyperammonemia, hepatic dysfunctions and other diseases.

Uses of L-Hydroxyproline.

L-hydroxyproline is a non-essential amino acid, an alpha subamino acid, and a columnar crystal at room temperature. It can be isolated from another amino acid, proline, and is produced by interaction with ascorbic acid vitamin C.

The uses of L-hydroxyproline include: 1) synthesis of tissue proteins in living organisms; 2) conversion to ammonia-containing substances such as acids, hormones, antibodies, creatine, etc.; 3) conversion to carbohydrates and fats; and 4) oxidation to carbon dioxide and water and urea to produce energy.

Applications of L-Hydroxyproline

As a nutritional fortifier, L-hydroxyproline is used in the formulation of fruit juices, soft drinks, and nutritional beverages, where its unique flavor enhances the overall taste. In the food industry, it is often used in combination with additives such as xylitol and sucralose. According to industry data from 2025, its application in the beverage sector accounted for 68%.

Some manufacturers (such as Shandong Zhengfa Biotechnology) also provide industrial-grade products, but food-grade products must meet the national standard GB, with an effective substance content of no less than 98%. In the health supplement sector, when used as an amino acid supplement, the daily dosage must comply with the National Food Safety Standard.

Physicochemical Properties of L-Hydroxyproline

L-Hydroxyproline has a water solubility of 36.1% at 25°C, is slightly soluble in ethanol, and exhibits a unique sensory characteristic of bitterness with a distinctive sweetness. Its molecular weight is 131.13, and it belongs to the imino acid class. In collagen, approximately 50% of proline is hydroxylated to 4-hydroxyproline. This substance undergoes a decomposition reaction at 274°C, existing in the solid state as flaky crystals or powder.

Product Method of Bulk L-Hydroxyproline Powder.

Made from gelatin, bone glue, casein, soybean epidermis and other proteins, hydrolyzed with hydrochloric acid, extracted by nitrosation method of sialic acid and then refined and crystallized by resin chromatography. The yield is about 7.0%.