API Levofloxacin hydrochloride Raw Materials Powder 177325-13-2

CAS:177325-13-2

MF: C18H21ClFN3O4

MW:397.83

EINECS:605-797-4

Specification: 99% min Levofloxacin hydrochloride Powder

Sample: Levofloxacin hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Levofloxacin hydrochloride Powder Usage and Synthesis.

Levofloxacin Hydrochloride has strong antibacterial activity against most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella spp., Serratia spp., Proteus spp., Shigella spp., Salmonella spp., Citrobacter spp., Fusobacterium spp. and gram-negative bacteria such as Pseudomonas aeruginosa, Haemophilus influenzae, Gonorrhea spp. and others.

It also has good antibacterial effect on some methicillin-sensitive staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus haemolyticus and other Gram-positive bacteria and Legionella, Mycoplasma, Chlamydia and so on. But the effect on anaerobic bacteria and enterococci is poorer.

Uses and functions of Levofloxacin hydrochloride.

Levofloxacin Hydrochloride is suitable for the following mild, moderate and severe infections caused by sensitive bacteria Respiratory system infections: acute bronchitis, chronic bronchitis, acute exacerbation of chronic bronchitis, diffuse fine bronchitis, bronchodilatation co-infections, pneumonia, pharyngolaryngitis, tonsillitis (peri-tonsillar abscess).

Urinary system infections: pyelonephritis, complicated urinary tract infections, etc.

Reproductive system infections: prostatitis, epididymitis, uterine cavity infection, uterine adnexitis, pelvic inflammatory disease (metronidazole can be used in combination when anaerobic infection is suspected).

Skin and soft tissue infections: infectious impetigo, cellulitis, lymphangitis (node), subcutaneous abscess, perianal abscess.

Intestinal infections: bacillary dysentery, infectious enteritis, salmonella enteritis, typhoid fever and paratyphoid fever. Other infections: trauma.

Pharmacological Effect of Levofloxacin hydrochloride.

1、Mechanism of action: Levofloxacin is the levofloxacin (racemic), quinolone antibacterial drugs, the antibacterial action of levofloxacin is mainly produced by the levofloxacin.

The mechanism of action of levofloxacin and other fluoroquinolone antibacterial drugs is to inhibit bacterial DNA replication, transcription, repair and recombination of topoisomerase Ⅳ and DNA rotase (topoisomerase Ⅱ).

2、Resistance: Fluoroquinolone resistance is generated by mutations in specific regions of DNA rotase or topoisomerase IV, which also become quinolone resistance determining regions (ORDRs), or changes in the drug efflux system.

3, fluoroquinolone antibiotics, including tozofloxacin, other chemical structure and mode of action with aminoglycans, macrolides and β-lactam antibacterial drugs (including penicillin) are different.

Therefore fluoroquinolones may still be effective against the bacteria of the above antimicrobial drugs.

4, Resistance to levofloxacin arising from spontaneous mutation under in vitro conditions is rare. Although cross-resistance has been observed between levofloxacin and some other fluoroquinolones yo, bacteria resistant to other fluoroquinolone species may still be sensitive to levofloxacin.

Drug interactions of  Bulk Levofloxacin hydrochloride Powder.

1、Urinary alkalinising agents may reduce the solubility of the product in the urine, leading to crystalluria and nephrotoxicity.

2、Combination of this product with cyclosporine may increase the blood concentration of cyclosporine, cyclosporine blood concentration must be monitored and the dose must be adjusted.

3、Combination of quinolone antibacterial drugs with theophyllines may result in a significant decrease in hepatic elimination of theophyllines due to competitive inhibition with cytochrome P450 binding site, prolongation of blood elimination half-life (t1/2β), increase in blood concentration, and symptoms of theophylline toxicity, such as nausea, vomiting, tremor, restlessness, agitation, convulsions, palpitations and so on. This product on the theophylline metabolism, although the impact is small, but when combined with theophylline blood concentration should be measured and adjust the dose.

4, this product and anticoagulant warfarin combination of the latter's anticoagulant effect of enhancement is small, but the combination of patients should also be closely monitored prothrombin time.

5, probenecid can reduce the product from the renal tubular secretion of about 50%, when used in combination can be due to the increase in blood concentration of the product and produce toxicity.

6, this product can interfere with the metabolism of caffeine, resulting in reduced caffeine elimination, blood elimination half-life (t1/2β) prolongation, and may produce central nervous system toxicity.

7, containing aluminium, magnesium acid-making drugs, iron can reduce the oral absorption of this product, should not be combined.

8, this product and non-steroidal anti-inflammatory drugs fenbufen when used in combination, there are occasional convulsions, so should not be used in combination with fenbufen.