Food Additives Raw Vitamin B12 Raw Powder

CAS:13408-78-1

MF: C63H88CoN14O14P

MW:1355.37

EINECS:236-500-2

Specification​: 99% min Vitamin B12 Powder

Sample:Vitamin B12 Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Vitamin B12 Powder Usage and Synthesis.

Vitamin B12 is the most recently discovered of the B vitamins to date. Vitamin B12 is a polycyclic compound containing 3-valent cobalt, and the four reduced pyrrole rings are linked together to form a cochineal macrocycle (similar to porphyrin), which is the core of the vitamin B12 molecule.

This is the core of the vitamin B12 molecule. Therefore, compounds containing this ring are known as cochineal-like compounds. Vitamin B12 is light red needle-like crystals, soluble in water and ethanol, most stable in pH 4.5 ~ 5.0 weak acid conditions, strong acid (pH < 2) or alkaline solution decomposition, heat can be a certain degree of destruction, but the loss of a short period of high-temperature disinfection is small, in the case of bright light or ultraviolet light easy to be destroyed.The loss is about 30 per cent during ordinary cooking.

Uses and functions of Vitamin B12.

Vitamin B12 is widely found in animal foods. And its form cannot be absorbed by the body.In addition, vitamin B12 is also the only vitamin that contains essential minerals, and is also known as the red vitamin because it contains cobalt, and is one of the few coloured vitamins.

Although vitamin B12 is a B-complex vitamin, it can be stored in the liver, and symptoms of deficiency will not appear until more than half a year has passed since the storage capacity has been exhausted. The human body needs very little vitamin B12, as long as the diet is normal, there will be no deficiency. A small number of malabsorbers need special attention.

Physiological Function of Vitamin B12.

1.As a cofactor of methyltransferase, it is involved in the synthesis of methionine and thymine, etc. For example, it can make methyl tetrahydrofolate to tetrahydrofolate and transfer methyl to methyl receptor (e.g. homocysteine),so that the methyl receptor can become methyl derivatives (e.g. methionine, i.e. methyl homocysteine).

Thus vitamin B12 promotes protein biosynthesis and affects the growth and development of infants and children when deficient.

2.It protects the transfer and storage of folic acid in cells.

Vitamin B12 deficiency, human erythrocyte folate content is low, the liver storage of folic acid is reduced, which may be related to vitamin B12 deficiency, resulting in the transfer of methyl from homocysteine to methionine difficult,the methyl in the intracellular aggregation of tetrahydrofolate in the cell, impairing intracellular storage, because of tetrahydrofolic acid with a strong tendency to combine with methyl to form methyl tetrahydrofolate, which synthesises polyglutamic acid.

Identification Methods of Bulk Vitamin B12 Powder.

1.The measurement of serum vitamin B12 is the most direct method of identification. Serum vitamin B12 concentration is less than 100μμg/ml, can be diagnosed as vitamin B12 deficiency (normal value is 100-300μμg/ml).

2. The measurement of urinary methylmalonic acid is an indirect method, when vitamin B12 deficiency, due to special metabolic disorders, the urinary excretion of methylmalonic acid increases, but folic acid deficiency does not increase, so it can be used to distinguish between vitamin B12 deficiency and folic acid deficiency.

3.Vitamin B12 absorption test. The radioactive cobalt-labelled vitamin B122.0μg to the subject orally, while intramuscular injection of vitamin B121000μg, and then determine the radioactivity of the urine within 48 hours.

Those with normal vitamin B12 absorption can excrete 5-40% of the orally administered radioactive cobalt in 48 hours; those with defective vitamin B12 absorption (e.g., pernicious anaemia, post-gastrectomy, tropical nutritional megaloblastic anaemia) have less than 5%.

④Therapeutic test, the earliest adopted and the simplest and most convenient means of diagnosis in clinical work, can be used when the conditions for carrying out the various tests mentioned above are not available.

Vitamin B12 deficiency can be determined by the rise of red blood cells in reticulocytes after treatment with vitamin B12 and the transformation of megaloblastic red blood cells in bone marrow into red blood cells of normal morphology.