Medical raw materials Naproxen Powder 22204-53-1

CAS:22204-53-1

MF:C14H14O3

MW:230.26

EINECS:244-838-7

Specification: 99% min Naproxen Powder

Sample: Naproxen Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Naproxen Powder Usage and Synthesis.

Naproxen is a non-steroidal anti-inflammatory drug, for PG synthase inhibitor, can inhibit prostate synthase, with significant analgesic and antipyretic effects, oral absorption is complete and rapid, 1 time after the administration of plasma concentration of 2 ~ 4 hours to reach the peak, more than 99% of the plasma protein in the blood and plasma protein binding, t1/2 for 13 ~ 14 hours, about 95% from the urine in its original form and metabolite excretion.

Clinically used in the treatment of rheumatic and rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.

It can also be used to relieve pain caused by musculoskeletal sprains, contusions, injuries and menstrual cramps.

However, it should be noted that as with other NSAIDs, serious gastrointestinal adverse reactions may occur at any time during treatment with naproxen, so it is contraindicated in patients with active gastroduodenal ulcers, and patients with other gastrointestinal disorders should take it under close medical supervision.

Uses of Naproxen.

Naproxen is a non-steroidal anti-inflammatory and analgesic drug used to relieve fever as well as inflammation and pain associated with arthritis or other conditions with anti-inflammatory, antipyretic and analgesic properties.

Naproxen works by inhibiting cyclooxygenase, an enzyme associated with the production of prostaglandins, an inflammatory mediator.

Naproxen also has the following uses:

1, Naproxen can enhance the body's resistance, so as to supplement the weak body caused by the lack of kidney qi, gastrointestinal power system sleepy symptoms caused by all have a huge role.

2, naproxen against Helicobacter pylori have good inhibition effect. Can be very good treatment of atrophic gastritis, superficial gastritis, duodenal ulcer.

In addition to improve the role of the gastrointestinal power system can also promote the metabolism of gastric acid. Assist the body's digestion and absorption and digestion and absorption.

3, naproxen also has a very good treatment of rheumatism and rheumatoid symptoms, many of the long-term rheumatism disease to the people to take naproxen after a significant feeling of rheumatism to get a very good reduction, so long-term use of naproxen to control to not allow it to arise again.

4, clinical experiments found that naproxen can reasonably improve pancreatic activity, the obvious practical effect is to be able to reduce the level of blood glucose volume, and then make the volume of blood glucose value restored to all normal levels.

Adverse Reaction of Naproxen.

1. Gastrointestinal reactions: the side effects of this product are fewer and milder than those of other non-steroidal anti-inflammatory drugs. There are a few cases of anorexia, nausea, vomiting, diarrhoea and other gastric discomfort, and in severe cases, gastrointestinal bleeding, hepatic impairment and jaundice are occasionally seen.

2. Central nervous reaction: manifested as depression, drowsiness, headache, dizziness, sweating, fatigue, hearing loss and visual impairment.

3. Allergic reaction: this product and aspirin have cross allergy, skin itching, allergic rash, urticaria and shortness of breath, dyspnoea and so on.

Therefore, allergic to aspirin and the elderly should be used with caution, pregnant women are prohibited.

4. Other reactions: a very small number of patients with granulocytopenia, thrombocytopenic purpura, recalcitrant anaemia and so on.

Occasionally, renal damage, such as proteinuria, haematuria, nephrotic syndrome, interstitial nephritis and reversible renal failure.

Therefore, it is used with caution in people with coagulation mechanism disorder, thrombocytopenia, asthma, renal insufficiency and peptic ulcer.

Product Method of Bulk Naproxen Powder.

6-Methoxy-2-naphthylethanone was obtained by methylation and acetylation of 2-naphthol, and then condensed with chloroacetate, and then isomerised, hydrolysed, oxidised, neutralised and split.