Furosemide CAS 54-31-9 Powder Raw Materials

CAS: 54-31-9

MF: C12H11ClN2O5S

Specification​: 99% min Furosemide 

Sample:  Furosemide Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Furosemide Powder Usage and Synthesis:

Furosemide Powder is the raw material for the production of diuretics, also known as tachyphylaxis, which are used clinically to treat cardiac oedema, renal oedema, cirrhotic ascites, peripheral oedema due to dysfunction or vascular disorders, and to facilitate the expulsion of upper urinary tract stones. It is used in severe cases where other diuretics are ineffective. Furosemide, also known as furanilic acid, tachyphylaxis, tachyphylaxis, diuretics, diuretic sulphonamides and abdominal anhydrous acid, is a high potency diuretic of the aminosulphonyl group acting on the ascending medullary branch of the medullary collaterals, with a strong and transient diuretic effect, increasing the excretion of water, sodium, chloride, potassium, calcium, magnesium and phosphate. Clinically used for the treatment of cardiac oedema, renal oedema, cirrhotic ascites, peripheral oedema caused by dysfunction or vascular disorders, and to promote the excretion of upper urinary tract stones. It is used clinically for the treatment of peripheral oedema caused by cardiac oedema, renal oedema, cirrhotic ascites, dysfunction or vascular disorders and to facilitate the excretion of upper urinary tract stones. It can be administered intravenously for the treatment of cerebral oedema and can also accelerate the excretion of toxic substances in cases of cerebral oedema drug poisoning. White or off-white crystalline powder. Melting point 206°C. Soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water. Odourless, almost tasteless.

Furosemide is a diuretic. It is used for oedematous diseases, hypertension, prevention of acute renal failure, hyperkalaemia and hypercalcaemia, dilutional hyponatraemia especially when the blood sodium concentration is below 120 mmol/L, SIADH, acute drug toxicity such as barbiturate poisoning, etc.

Pharmacokinetics of Furosemide Powder :

Furosemide mainly inhibits the reabsorption of Na+ and Cl- in the medullary and cortical portions of the ascending thick section of medullary collaterals, promotes the excretion of sodium, chloride and potassium and affects the formation of high osmotic pressure in the renal medulla, interferes with the concentration and dilution process of urine, and increases urine volume. It inhibits the activity of prostaglandinolytic enzymes and increases the level of prostaglandin E2. It has a vasodilating effect and also has an effect on the proximal tubule and glomerular filtration, increasing renal blood flow and adjusting the distribution of blood flow in the kidney so that the medullary blood flow decreases and the blood flow in the superficial cortex increases, promoting diuresis with rapid and powerful effects, and is mostly used in cases where other diuretics are ineffective. The oral absorption rate of furosemide is 60%-70%. Eating slows down the absorption rate but does not affect the absorption rate or its efficacy. The oral absorption rate in patients with end-stage renal disease is reduced to 43%-46%. In oedematous diseases such as congestive heart failure and nephrotic syndrome, oral absorption is also reduced due to oedema of the intestinal wall, so the drug should be administered by parenteral route in these cases.

Clinical Application of Furosemide Powder:

(1) Oedematous diseases including congestive heart failure, cirrhosis, renal diseases (nephritis, nephropathy and acute and chronic renal failure from various causes), especially when other diuretics are not effective, may still be effective. Combined with other drugs for acute pulmonary oedema and acute cerebral oedema, etc.

(2) Hypertension is not usually the first choice for the treatment of essential hypertension, but this class of drugs is particularly useful when thiazides are not effective, especially in the presence of renal insufficiency or hypertensive crisis.

(3) Prevention of acute renal failure is used for various causes of inadequate renal perfusion, such as water loss, shock, poisoning, anaesthesia accidents and circulatory insufficiency, etc. Timely application while correcting blood volume insufficiency can reduce the chance of acute tubular necrosis.

(4) Hyperkalaemia and hypercalcaemia.

(5) Dilutional hyponatraemia especially when the blood sodium concentration is below 120 mmol/L.

(6) Sydriatic antidiuretic hormone hypersecretion (SIADH).

(7) Acute drug toxicity such as barbiturate poisoning.

Furosemide Powder Raw Materials can be made into the following properties of drugs.

(1) Furosemide tablets: white tablets.

(2) Furosemide injection: clear, colourless or almost colourless liquid.

(3) Furosemide for Injection: white or off-white loose lumps or powder.

Patients do not need to drink more water when taking furosemide medication as it is a sodium and water-supportive drug that removes excess water from the body and is used in most cases in patients with swelling. Common causes of swelling are as follows.

1, heart failure: most cases can be seen in cardiac insufficiency, heart failure patients, can use furosemide for dehydration treatment, and in heart failure treatment need to limit water, diuretic, patients avoid drinking more water. Early stages of heart failure, i.e. acute exacerbation, require strict control of water intake, which should not exceed 1500ml per day, and if heavier, may not exceed 1800ml or 2000ml, depending on the patient's specific situation.

2, renal disease: some patients with renal disease need to be properly hydrated when edema is more serious, there is no need to drink more water at this time. For patients with simple swelling of the lower limbs, furosemide will also be applied intermittently to improve the symptoms.

Furosemide is an on-demand drug, usually taken when the patient has more water in the body, no need to drink more water, if the patient appears thirsty can also drink water, but drinking more water is not better for the condition.More Hormones and Endocrine System Raw Drugs Materials