Ambroxane Raw Materials Ambroxane Powder

CAS:6790-58-5

MF:C16H28O

MW:236.39

EINECS:229-861-2

Specification: 99% min Ambroxane Powder

Sample:Ambroxane Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ambroxane Powder Physiological effect.

Ambergris Ether is a commonly used spice, with ambergris flavour, often used in high-grade perfume and cosmetic fragrances, non-irritating to the human body, suitable for skin, hair and fabrics, such as soaps, talcum powder, creams and shampoos, such as perfuming and scenting.

It is also used as the base of the fragrance, in the "gun Juliet" of other perfumes have been applied.

Ambergris ether is known as the "mother fragrance", because it will have different presentations in different people, with the change of body temperature, skin texture and fragrance differences, and exudes a different scent texture, the formation of "a thousand people, a thousand scents".

In addition, northeastern ambergris ether is the best alternative to ambergris available today, and is widely used in perfumery.

Uses and Function of Ambroxane.

Ambergris Ether has a strong, special ambergris aroma. Used in high-grade perfume and cosmetic flavouring, because it has no stimulation to the human body, no allergic reaction to animals, so it is very suitable for the skin, hair and fabric flavouring spice.

Often used in soap, talcum powder, creams and shampoos for scenting and scenting. The general dosage is 0.1%-0.2%. Freshly distilled pure product, its aroma is not prominent, when diluted with alcohol to 10%, and exposed to air for some time, the aroma will become more soft and mellow and beautiful.

It has an outstanding aroma fixation, which greatly improves the diffusion and penetration of the flavour, and enhances and strengthens the aroma from the first notes of the flavour all the way through.

Ambergris aroma raw materials in the application of cigarettes Lai Baidang class of substances is the key aroma-causing components of spice cigarettes, descending ambergris ether is one of the role of a particularly prominent spice, the smoke of the mixed cigarettes has an important contribution.

Ambergris ether is also widely used in baking cigarettes and perfume industry. Descending ambergris ether is used in the cigarette industry for flavouring and flavouring, it is in harmony with the characteristic aroma of tobacco, and can mask the miscellaneous gas, even if it is used in minute quantities, it can improve the quality of the aroma of tobacco, it is especially suitable for flavouring of blended cigarettes and enhancing the flavour of oriental tobacco.

Preparation method of Ambroxane.

Method 1: A two-step oxidation, i.e. alkaline and weakly acidic, is carried out on balsamol, and the oxidising agent may be potassium permanganate, ozone or a sulphuric acid solution of sodium (or potassium) dichromate, after which the oxides are saponified, dehydrated, and lactonised to produce norepineolide.

The lactone is then reduced to norethindrone diol with lithium aluminium hydride in ether (or with borane in tetrahydrofuran).

With D - camphor - β - sulfonic acid as a cyclic agent, dehydrogenation of diol, and then dehydrated under the action of aluminium trioxide, can be produced norepineol ether. With this method in addition to get descending ambergris ether, but also can get descending ambergris ether isomer bicyclic high gold acacia alcohol, that is, LaiBaiDang-6-en-12-ol Chemicalbook (colourless crystals, melting point 20 ° C, also has ambergris taste).

Method 2: The synthetic route with diol 2 as the intermediate was the first artificial synthesis of norephedrine ether from (-)-perillyl alcohol 3 originating from the extract of Perilla frutescens, with an overall yield of 52%. The balsamol 3 was oxidised with chromium trioxide and degraded to the lactone 4, which was reduced by lithium tetrahydroaluminium to obtain the diol 2; the diol compound 2 was activated by p-toluenesulphonyl chloride, and then subjected to intramolecular cycloaddition under the action of alkali sodium hydride to obtain the nigrosalpinum 1.

The disadvantage of this route is the need to use chromium trioxide as an oxidant, will generate a large number of seriously polluted chromium-containing wastewater, and the need to use the more dangerous lithium tetrahydroaluminium and sodium hydride, etc.

Synthesis method of  Bulk Ambroxane Powder.

Ambergris Ether is a synthetic spice with the special aroma of natural ambergris and is recognised as one of the best substitutes for natural ambergris, it is one of the most critical trace components of natural ambergris tincture.

Natural ambergris is a precious animal spice, a stone in the stomach and intestines of sperm whales, which is vomited or excreted by whales on the surface of the sea, and emits a special aroma in the air over time.

The synthetic descending ether is made from perillyl alcohol, which is oxidised by KMnO4 in two steps (ozone oxidation in Switzerland and sodium dichromate oxidation in Russia). That is (1) alkaline oxidation; (2) weak acidic oxidation.

Obtain the oxide, and then the oxide saponification, dehydration, lactonisation, then the descending salivary lactone. The lactone is reduced to norepineol with lithium aluminium hydride in ether (or with borane in tetrahydrofuran).

Use D-camphor-β-sulfonic acid as cyclisation agent, cyclise the diol, that is, get norepinephrine ether (foreign cyclisation agents include sulphuric acid, p-toluenesulphonic acid and β-naphthalenesulphonic acid, etc.). The total yield of the whole process is 35%.