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Citicoline Raw material powder Citicoline
Product Overview:
Citicoline is a nucleic acid derivative. In 1956, Geiger found in animal experiments that citicoline can restore brain damage; Kennedy's research in 1957 confirmed that it is crucial in the synthesis of brain phospholipids. In 1961, Takeda Pharmaceutical Company of Japan developed and produced this product and registered it in my country in 1988. It is currently the best-selling drug for the treatment of brain diseases in clinical practice. It plays an important role in the synthesis of lecithin and improves brain function by promoting the synthesis of lecithin. Experiments have shown that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby treating cerebrovascular diseases, brain trauma and cognitive impairment caused by various reasons, and has no obvious side effects.
Citicoline Raw material powder Citicoline Attributes
CAS:33818-15-4
MF:C14H26N4O11P2.Na
MW:511.31
EINECS:251-689-1
Specification: 99% min Citicoline powder
Sample:Citicoline powder
Packaging:1kg/bag, 25kg/drum
Brand: Raw material
Appearance: White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Citicoline Raw material powder Citicoline Details
Citicoline Powder Usage and Synthesis.
Citicoline sodium can enhance the function of the brainstem reticular formation, especially the ascending reticular formation activation system closely related to consciousness, enhance the function of the pyramidal system, inhibit the function of the extrapyramidal system, and promote awakening. At the same time, it can reduce cerebral vascular resistance, increase cerebral blood perfusion, and promote brain metabolism.
It is mainly used to treat sequelae of the nervous system caused by craniocerebral injury and cerebrovascular accident, and can be used to treat Parkinson's syndrome. It has a certain effect on Alzheimer's disease; it is used to treat cerebrovascular and cardiovascular diseases; it also has a certain effect on delaying aging, improving learning effects and memory, etc.
Uses of Citicoline.
Coenzyme. Used for acute craniocerebral trauma and postoperative consciousness disorder. It can gradually restore the function of the limbs for hemiplegia caused by cerebral stroke, and can also be used for other functional and consciousness disorders caused by acute damage to the central nervous system, as well as ischemic cerebrovascular disease and vascular dementia.
In vitro studies of Citicoline.
Citicoline is a major component of cell membrane phospholipids and is a complex organic molecule composed of ribose, pyrophosphate, cytosine and choline. Citicoline is water-soluble and has an oral bioavailability of more than 90%.
Citicoline has no mitogenic and chemotactic effects on hCMEC/D3. However, it can significantly enhance wound healing, spheroid sprouting, and strongly induce the formation of endothelial tubular structures in the basement membrane matrix. Citicoline can induce the expression of phosphorylated ERK1/2.
It can protect hCMEC/D3 from cell damage/apoptosis. Citicoline induces angiogenesis and improves the survival of human brain microvascular endothelial cells through p-ERK1/2 and IRS-1 related pathways.
Product Method of Bulk Citicoline Powder.
