spironolactone raw Materials powderspironolactone

CAS:52-01-7

MF:C24H32O4S

MW:416.58

EINECS:200-133-6

Specification: 99% min spironolactone powder

Sample:spironolactone powder

Packaging:1kg/bag, 25kg/drum

Brand:Raw Materials

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

spironolactone powder Usage and Synthesis.

Spironolactone is a competitive inhibitor of aldosterone, and the drug itself has no activity. The diuretic effect occurs due to competitive antagonism with endogenous aldosterone, and it is a potassium-preserving diuretic.

(1) edematous diseases, combined with other diuretics, the treatment of congestive heart failure, cirrhosis ascites, renal edema and other edematous diseases, the purpose of which is to correct the secondary increase in aldosterone secretion accompanied by the above diseases, and counter the potassium excretion effect of other diuretics; It is also used in the treatment of idiopathic edema.

② Hypertension, as an adjunct treatment of hypertension.

Spironolactone can be used for diagnosis and treatment of primary hyperaldosteronism.

④ Prevention of hypokalemia, combined with thiazine diuretics, enhance diuretic effect and prevent hypokalemia.

Uses of spironolactone.

It is a synthetic 17-lactone steroid, a nephrocompetitive aldosterone antagonist, and belongs to the class of potassium-conserving diuretics, mainly used to treat liver disease, low renin hypertension, and hypokalemia.

A low potency diuretic similar in structure to aldosterone and a competitive inhibitor of aldosterone

Pharmacological action of spironolactone.

The diuretic strength of spironolactone is related to the amount of aldosterone secretion in the body, the effect is strong when secreted more, the effect is weak when secreted less, and the patients without aldosterone secretion have no diuretic effect. Since this drug only acts on the distal tubules and collecting tubules, and has no effect on other segments of the renal tubules, it has weak diuretic effect, slow onset and long maintenance time. It is mainly used for refractory edema accompanied by increased aldosterone, such as cirrhosis ascites, congestive heart failure, nephrotic syndrome, etc. It has a good effect on congestive heart failure patients with secondary increased aldosterone caused by sodium deficiency. The diuretic effect of this product is often poor when used alone, and often combined with hydrochlorothiazide or dihydrochlorothiazide can enhance the efficacy. In addition, it is used in the treatment of primary aldosteronism and essential hypertension.

Product Methods of spironolactone.

It can be synthesized from acetylene androdiol by form reaction, carboxylation, salting, hydrogenation, lactonification, oxidation, elimination, addition and other steps.