Pharmaceutical raw materials Quinine raw Powder

CAS:130-95-0

MF:C20H24N2O2

MW:324.42

EINECS:205-003-2

Specification​: 99% min Quinine

Sample:Quinine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Quinine Usage and Synthesis.

Quinine is an alkaloid of Cinchona bark. It belongs to the 4-methanolquinoline class of antimalarial drugs. It has a rapid action against Plasmodium falciparum, Plasmodium vivax, Plasmodium ovum and Plasmodium malariae. It can kill blood schizozoites.

Quinine can inhibit or kill benign malaria (vivax malaria, malariae malariae) and Plasmodium falciparum red phase, can control malaria symptoms, but has no direct effect on the gametophyte of falciparum malaria, so it can not interrupt transmission.

In addition, this product has the effect of antipyretic and uterine contraction.

Uses of Quinine.

Quinine is mainly used in patients infected with plasmodium that is resistant to chloroquine. It is also used in vivax malaria and falciparum malaria. All the salts used in medicine are quinine. Sulfate for oral use, hydrochloride for injection. Until the 1920s, it was a better treatment for malaria. However, if used improperly, it can also be toxic, causing headaches, tinnitus, diarrhea, rash, vision and hearing disorders. It has only inhibitory effect on protomalaria, but no killing effect, and patients are still prone to disease after recovery. For this reason, scientists are still looking for more effective antimalarial drugs, which have been used with alacrine, pamaquoline, chloroquinoline and so on. A kind of alkaloid can be extracted from a plant from China. Its antimalarial effect is more than 100 times greater than quinine, but it cannot be taken directly because of its toxicity. The structure and pharmacological relationship of alkaloid are being studied in order to find a more effective antimalarial drug.

Pharmacological action of Quinine

Quinine is one of the oldest antimalarial drugs, as early as the 15th century quinine-containing cinchona bark has become a widely used anti-malaria wonder drug, its antimalarial effect is similar to chloroquine, it works by interfering with DNA synthesis. It can inhibit the red blood cell phase of various plasmodium parasites and control the onset of malaria symptoms. It also has certain killing effect on the gametophyte of vivax malaria and malariae malariae. But it had no effect on extracellular phase. Its main advantage is that it is not easy to produce drug resistance, perhaps quinine and the DNA binding mode of malaria parasites is different from chloroquine, so there is no cross-resistance, and it can be used to resist chloroquine strains (especially Plasmodium falciparum) infection. In addition, quinine has the effects of uterine excitation, myocardial inhibition, antipyretic and analgesic. In addition to medicinal use, it can be used as a detection agent for metal ions such as bismuth and platinum in analytical chemistry, and can also be used as a separation agent for racemic organic acids.

The oral absorption of this product is fast and complete, and the blood concentration can reach the peak in 1 to 3 hours. The binding rate to plasma protein is about 70%. The concentration in cerebrospinal fluid is about 2% to 5% in plasma. The half-life is 7 to 8 hours. It transits the placenta quickly and is absorbed slowly by subcutaneous and intramuscular injections. It is mainly metabolized through the liver, and 5% of the administered dose is excreted from the urine in its original form.

Extraction method of Quinine.