Loteprednol etabonate Raw Materials powder

CAS:82034-46-6

MF:C24H31ClO7

MW:466.95

EINECS:200-010-0

Specification​: 99% min Loteprednol etabonate powder

Sample:Loteprednol etabonate powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Loteprednol etabonate Powder Usage and Synthesis.

1. When the use of corticosteroids can safely reduce edema and inflammation, this product can be applied to the treatment of eyelid and bulbar conjunctivitis, uveitis, cornea and anterior ganglia inflammation of corticosteroid sensitive inflammation. (such as seasonal allergic conjunctivitis, rosacea keratitis, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, atopic keratitis, etc.).

2. This product is also suitable for treating postoperative inflammation after various eye operations.

Use of Loteprednol etabonate.

1. Anti-inflammatory

Cloteprednol plays an anti-inflammatory role by inhibiting the migration and activation of inflammatory cells and reducing the production of inflammatory mediators.

2. Anti-allergy

Cloteprednol blocks histamine receptors and reduces symptoms of histamine-mediated allergic reactions.

3. Relieve itching

Loteprednol can reduce the release of the neurotransmitter Substance P and relieve itching.

Step 4: Pain relief

Loteprednol has nonsteroidal anti-inflammatory properties that inhibit prostaglandin synthesis, thereby reducing pain.

5. Immune regulation

Cloteprednol regulates immune response through its effect on T lymphocyte activity.

Pharmacological Effect of Loteprednol etabonate.

The high fat solubility of cloteprednol makes its corneal permeability better, and it is easy to be hydrolyzed into inactive organic acids, and can be rapidly metabolized into inactive products after eye drop, reducing systemic toxicity. Compared with other glucocorticoids, its anti-inflammatory effect is stronger, and the effect of increasing iOP is less, so it is safer and has better efficacy. The metabolic site of this product is in the cornea, which avoids the ultrastructural changes of trabecular network caused by the high concentration of hormones in aqueous humor, which obstructs the outflow of aqueous humor and causes the increase of intraocular pressure. Compared to flumilone, it showed a lower tendency to increase IOP. The mechanism of action of its combination with cyclosporine in the treatment of dry eye is to inhibit the apoptosis of lacrimal acinic cells and conjunctival goblet cells, promote the apoptosis of lymphocytes, and thus inhibit the inflammation of the eye surface, but it is easy to cause irritation symptoms such as stinging and burning sensation. It has no effect on intraocular pressure, little irritation, mild effect and strong anti-inflammatory effect, so it is used more and more widely in ophthalmic treatment.

Product Method of Bulk Loteprednol etabonate Powder.