Supply Raspberry Ketone Raw Materials powder

CAS:5471-51-2

MF:C18H15Cl4N3O4

MW:479.14

EINECS:245-256-6

Specification: 99% min Raspberry Ketone

Sample:Raspberry Ketone powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:colorless liquid

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Raspberry Ketone of Usage and Synthesis.

Raspberry ketone is not only widely used in the preparation of edible flavor and daily flavor, but also used in the synthesis and manufacture of medicine, stimulants, cosmetics, cigarettes, dyes, etc. In addition, raspberry ketone and its acetyl compounds are drosophila sexual attractants and can be synthesized as pesticides. At the same time, because the raspberry ketone contains aromatic ring, hydroxyl group and ketone group in its molecular structure, it has special chemical activity and is also an important intermediate of fine chemicals. With the further development of the fragrance industry and organic synthesis industry, the research value of raspberry ketone has also steadily increased, in addition to being used as a fragrance, it is also widely used in other fields.

Uses of Raspberry Ketone.

Widely used in strawberry, raspberry, pineapple, peach and other edible flavors, usually in fruity flavor as a fixing agent. In the daily chemical flavor can be used in jasmine, flower, tuberose and other formulations. As a modifier, it is used in jasmine, gardenia, tuberose and other flower fragrance daily flavor. In food flavor, it is used in strawberry, pineapple, peach, plum, hanging fish and other flavors.

Preparation of Raspberry Ketone.

Using p-hydroxybenzaldehyde and acetone as raw materials

The 4-p-hydroxyphenyl-3-butene-2-ketone was synthesized by Claisen-Schmidt condensation under base catalysis and optimized by orthogonal experiment (88.4% yield). Raspberry ketone was synthesized by hydrogenation under palladium-carbon catalysis (84.0% yield). P-hydroxyphenyl-3-butene-2-ketone was synthesized with NaOH solution as Claisen-Schmidt condensation catalyst. The yields of raspberry ketone were 72.55% and 65.7% using 5% Pd /C and nickel formate as the second step catalysts, respectively.

Orthogonal test was used to study the condensation reaction conditions of p-hydroxybenzaldehyde and acetone, and the optimal process conditions were as follows: The ratio of n(p-hydroxybenzaldehyde)∶n(acetone)∶n(NaOH) = 1.0∶ 25∶ 25(reaction at 30 ℃ for 5 h) was followed by conventional hydrogenation reduction, vacuum distillation and mixed solvent recrystallization to obtain raspberry ketone (yield 61.8%). Claisen-Schmid condensation reaction was catalyzed by NaOH, nickel formate as catalyst and isopropyl alcohol as solvent to produce raspberry ketone with yield of 42.0%.

Product method of Bulk Raspberry Ketone Powder.

Hydrogenation route

First, 3.5mol 15% sodium hydroxide was added to the reactor, and 2mol acetone and 1mol para-hydroxybenzaldehyde were added to the mixture under stirring, and the temperature was controlled at 20-30 ℃. After the drip, the reaction was continued to stir for 20h. The solid sodium salt of 4-p-hydroxyphenylbutene-3-keto-2 was obtained by filtration, dissolved with water, then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-keto-2, and dried after filtration for use.

Add the above intermediate 100g and nickel catalyst 5g in the autoclave, replace the air with hydrogen, and heat it to 120 ~ 140℃, and react at 0.98MPa pressure for 1.5h. After cooling, the catalyst was filtered, the content of raspberry ketone was 89%, and the hydrogenation yield was 92%. The crude product is distilled once under vacuum and recrystallized 1 ~ 2 times to obtain white crystal with a melting point of 82℃.