HRK Supply Sulfasalazine raw Powder

CAS:599-79-1

MF:C14H12N4O2S

MW:300.34

EINECS:200-423-2

Specification: 99% min Sulfasalazine Powder

Sample:Sulfasalazine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:orange

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Sulfasalazine powder Usage and Synthesis.

Salazopyridine is an organic compound with the chemical formula C18H14N4O5S. It is mainly used as a sulfanilamide antimicrobial drug. It is a sulfanilamide drug that is not easily absorbed by mouth. 5-aminosalicylic acid (5-aminosalicylic acid) stays in the intestinal wall connective tissue for a long time after complexing, and plays an antibacterial and anti-inflammatory and immunosuppressant effect, such as reducing Escherichia coli and Clostridium difficile, and inhibiting the synthesis of prostaglandins and the synthesis of leukotrienes, other inflammatory mediums. Therefore, it is currently believed that the main component of this product to produce curative effect on inflammatory bowel disease is 5-amino-salicylic acid, and the sulfapyridine produced by the decomposition of this product shows weak antibacterial effect on intestinal flora.

Uses of Sulfasalazine.

Intestinal sulfanilamide, which has a special affinity with connective tissue, is a good drug for the treatment of chronic ulcerative conjunctivitis. Salazopyridine is a chemical combination of sulfanilamide and salicylic acid, which has been available for nearly 80 years. It belongs to the sulfanilamide family of drugs, but it has no antibacterial activity itself. In the gut, it is broken down into sulfapyridine and 5-aminosalicylate, which has a weaker antibacterial effect, and 5-aminosalicylic acid, which has anti-inflammatory and immunosuppressive effects.

Salazopyridine is the primary drug for the treatment of mild and moderate ulcerative colitis, and it has the characteristic of being released in the colon, usually 3-4g/ day, orally divided. The initial dose can be as small as 1-2g daily. In addition to the treatment of ulcerative colitis, it has also been used in the treatment of rheumatoid arthritis and ankylosing spondylitis, psoriatic arthritis and other rheumatic diseases. Salazopyridine improves joint pain, swelling, and stiffness in patients with ankylosing spondylitis, reduces serum IgA levels and other markers of laboratory activity, and is particularly suitable for improving peripheral arthritis in patients with AS.

Pharmacological action of Bulk Sulfasalazine powder.

Product Methods of Sulfasalazine.

2-aminopyridine reacts with n-acetylamino-benzene sulfonyl chloride, which is then hydrolyzed to obtain sulfonylpyridinium, which is then diazotized and coupled with salicylic acid and acidified to produce sulfasalazine.