Raw material intermediate Clozapin powder

CAS:5786-21-0

MF:C18H19ClN4

MW:326.82

EINECS:227-313-7

Specification: 99% min Clozapine powder

Sample:Clozapine powder

Packaging:1kg/bag, 25kg/drum

Brand:Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Clozapine powder Usage and Synthesis.

Clozapine has a strong antipsychotic effect, while EPS is less common and does not cause stiffness. Because it can directly inhibit the ascending activation system of the mesencephalic reticular structure, it has a strong sedative and hypnotic effect. It can be used in schizophrenia, and has good effect on hallucination, delusional symptoms and youth type. In addition to positive symptoms such as excitement and agitation, hallucination and delusion, it also has a good effect on negative symptoms. Because the mechanism of action of this product is different from that of classical antipsychotics in blocking DA receptors, it may be effective for some patients with poor efficacy of classical antipsychotics. It can also be used for manic episodes and to improve stubborn sleep disorders. In addition, there are anticholinergic, NE-block, sympathetic nerve block, muscle relaxant and antihistamine effects.

Uses of Clozapine.

1. For acute and chronic insanity. It is used for trance of mind, reversal of soul and dream, compassion and desire to cry, palpitation, fatigue of the body, sudden onset of illness, sudden rage and ignorance, two eyes and other diseases.

2. It is used for crazy diseases caused by various reasons. Such as impatience, or destroy the house to beat people, or cry and laugh impermanence, emotional anxiety, tension, sometimes mania and other disorders.

3. Behavioral disorders for mental retardation. Such as speech delay, poor expression ability, slow thinking and comprehension, lack of abstract, summary ability. The perception is slow and narrow, and it is difficult to distinguish the small differences in the shape, size and color of objects. Lack of concentration and narrow attention span. Poor memory, slow memorization and inaccurate reproduction. Behavior is childish, immature, emotional instability, lack of self-control, impulsive. Often show timid, withdrawn, shy, withdrawal and so on. Uneven body shape, uncoordinated movement, poor flexibility, or excessive activity, destructive, aggressive behavior or other undesirable behavior.

4. For drug or alcohol dependence withdrawal syndrome. Such as acute tremor, emotional agitation, jitters, nausea, vomiting and sweating. Once you drink alcohol, the symptoms disappear immediately, otherwise they last for several days. There are even temporary delusions, hallucinations, deformations of vision, and indistinct pronunciation. Seizures or delirium may eventually occur.

5. Used for sleepless nights. Suitable for various manifestations of insomnia, such as many dreams easy to wake up, palpitation forgetfulness, limb fatigue and exhaustion.

Pharmacological action of Clozapine.

1. Antipsychotic effect: Clozapine is effective for all kinds of acute and chronic psychosis, and can relieve mental symptoms such as excitement, agitation, hallucinations, delusions, thinking disorders, depersonalization, and strange movements. The mechanism of action may be related to blocking dopamine receptors in the midbrain limbic system, but does not affect dopamine receptors in the striatum, so this product rarely produces extrapyramidal reactions.

2. Sedative hypnotic effect: small dose of this product can inhibit spontaneous activity, large dose can increase spontaneous activity. Clozapine can directly inhibit the ascending activation system of mesencephalic reticular structure.

3. Anticholine, antihistamine and antiadrenergic action: This product has a strong anti-acetylcholine effect, and also has blocking effect on histamine, norepinephrine and epinephrine.

Product Methods of Clozapine.

2-amino-4-chlorodiphenylaniline-2 '-carboxylic acid (4 "-methyl) piperazine reacts with phosphorus oxychloride to obtain Clozapine.