HRK Supply Colchicine raw Materials powder

CAS:64-86-8

MF:C22H25NO6

MW:399.44

EINECS:200-598-5

Specification​: 99% min Colchicine Powder

Sample:Colchicine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Colchicine Powder Usage and Synthesis.

Colchicine has a good effect on acute gout, can quickly relieve pain and prevent the onset of arthritis, and its mechanism of action is related to inhibiting leukocyte proliferation and activity and affecting lysosome release. The pharmacological effect of this product is to reduce the activity and phagocytosis of white blood cells in inflammatory tissues, reduce the inflammation caused by uric acid crystals, and thus play anti-inflammatory, detumification and analgesic effects, so it has selective anti-inflammatory effects on acute gouty arthritis.

Uses of Colchicine.

1. It has anti-inflammatory effect. It is an alkaloid that inhibits cyclooxygenase and reduces the release of prostaglandins, which can play a role in reducing pain, swelling and inflammation.

2. It can inhibit the mobility and phagocytosis of neutrophils. By reducing the accumulation of neutrophils in the inflammation site, it prevents the injury of inflammatory mediators to the body.

3. It can treat gout. It can help patients quickly relieve pain, and effectively relieve local joint swelling heat pain.

In addition, colchicine is often used in combination with anti-inflammatory drugs for better results. However, it should be noted that colchicine has certain side effects, so it is recommended to use under the guidance of a doctor.

Preparation of Colchicine.

1. Organic solvent extraction method According to the properties of colchicine and its analogs, ethanol, methanol and benzene are generally used as solvents for extraction. This method has simple operation, low cost, less solvent consumption, but low extraction rate; There are also a few literatures on water, chloroform, ethyl acetate and so on as solvents. The effects of solvent type, extraction time and extraction method on the extraction efficiency of lily were investigated. The extraction agent was ethanol and the extraction time was 8h. The extraction efficiency was significantly improved by alkalizing lily powder, and the extraction rate was increased from 0.95% to 1.77%.

2. Supercritical carbon dioxide fluid extraction Supercritical fluid extraction (SFE) is a new extraction technology developed in recent years. The results show that supercritical fluid extraction can be used not only for fat-soluble alkaloids but also for water-soluble alkaloids, and the method is 1~10 times higher than the conventional method. Compared with the classical sample processing methods (such as Soxhlet extraction, liquid-liquid extraction, etc.), it has the following characteristics: (1) fast and efficient; (2) Good selectivity; (3) small pollution, small sample consumption; (4) Can be used in conjunction with other analytical techniques. This paper takes supercritical fluid extraction as an example to illustrate the technological process: CO2-SFE was used to extract colchicine, 76% ethanol was used as entrained agent, the particle size was 10 mesh, the extraction pressure was 45kpa, the extraction rate of colchicine was 0.585%. The results showed that the average extraction rate of CO2-SFE with 76% entraining agent was 1.25 times higher than that of reflux extraction, and the extraction time was reduced.

Product method of Bulk Colchicine Powder.

This product is an alkaloid extracted from the bulbs of the liliaceous plant Lijiang Shanci Mushroom. Shanci mushrooms powder was heated with 85% ethanol for reflux extraction for 4h, and the obtained ethanol solution was concentrated into a semi-gel under reduced pressure, diluted with distilled water, extracted with chloroform after acidifying with 10% sulfuric acid, and then recrystalized the crude colchicine obtained by concentrating and crystallizing the chloroform extract. The total yield was 0.15%. Most of the foreign plants are extracted from the bulbs of the lily family colchicum.