Supply Cimetidine Raw Materials powder

CAS:51481-61-9

MF:C10H16N6S

MW:252.34

EINECS:257-232-2

Specification: 99% min Cimetidine

Sample:Cimetidine powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Cimetidine of Usage and Synthesis.

Cimetidine, marketed in 1975, was the first selective H2 receptor antagonist for the treatment of peptic ulcers. It can inhibit the secretion of gastric acid and reduce its acidity, prevent and protect corrosive gastritis caused by chemical stimulation, and also have obvious curative effect on stress gastric ulcer and upper gastrointestinal bleeding.

1. Pantothenic acid for stomach pain. This product is good at producing acid and relieving pain, and has the function of soothing the liver and regulating the qi and stomach. It is a common medication for disharmony between the liver and stomach, excessive stomach acid, stomach duct pain, and belching and swallowing acid.

2. Used for gastric muscle damage. This product also has a good role of protecting the stomach to remove rot, astringent and generate muscle, used for stomach pain caused by stomach muscle damage, not only can maintain the stomach muscle, but also can and stomach pain.

3. For vomiting blood, blood in the stool. This product has the effect of astringent hemostasis, suitable for stomach injury caused by blood vomiting, blood stool.

Uses of Cimetidine.

Histamine receptor antagonist of H2; I1 imidazoline receptor agonist; Anti-ulcer agent. By inhibiting the expression of electron endothelial cell surface selectin, cancer cell metastasis is prevented, thus blocking the adhesion of tumor cells. Histamine H2 receptor antagonist. It can inhibit the gastric acid secretion caused by histamine stimulation, and inhibit the gastric acid secretion induced by food, pentagastrin, caffeine and insulin, and also inhibit the basic gastric acid secretion. For gastric and duodenal ulcer, peptic esophagitis, Zhuo - Ai syndrome.

Pharmacological action of Cimetidine.

This product is histamine H2 receptor antagonist, can reversibly inhibit histamine H2 receptor effect. Therefore, it can inhibit the secretion of gastric acid caused by basic gastric acid and various stimuli, and prevent gastrointestinal ulcer. It can enhance the cellular immune function, inhibit the activity of inhibitory T cells, stimulate the immune function of lymphocytes, have anti-androgen effect, block the binding of DHT and hair follicle receptors, and inhibit the secretion of skin glands. It also has antiviral effect, analgesic effect and antipruritic effect of local anesthesia. This product is absorbed rapidly after oral administration, and the blood concentration reaches the peak 60 to 90 minutes after administration, and the biological half-life is about 2 hours. Taking medication with meals significantly delays the peak time and prolongs the half-life. Taking 0.4g on an empty stomach, the effective blood concentration can be maintained for more than 4 hours, and the acid inhibition effect lasts for 5 to 6 hours. The product can pass the blood-brain barrier, and the concentration in cerebrospinal fluid is about 1/4 of that in blood. It can also cross the placental barrier and secrete milk. About 80% is excreted through the kidney in drug form within 24 hours. Patients with renal insufficiency have reduced excretion and prolonged drug action.

Product method of Bulk Cimetidine Powder.

The intermediate (I) and 2-aminoethylmercaptol hydrochloride react in the presence of hydrogen bromide and then neutralize with potassium carbonate to obtain the compound (II). Then it reacts with the corresponding thiourea to get cimetidine.