Pharmaceutical Heparin sodium Raw Materials powder

CAS:9041-08-1

MF:(C12H16NS2Na3)20

MW:/

EINECS:232-681-7

Specification: 99% min Heparin sodium powder

Sample:Heparin sodium powder

Packaging:1kg/bag, 25kg/drum

From:Henrikang

Appearance:white

Shelf Life: 2 Years

Test Method: HPLC

Heparin sodium powder Usage and Synthesis.

Heparin is a kind of mucopolysaccharide sulfate. According to its relative molecular weight, it can be divided into ordinary heparin and low molecular weight heparin. Heparin calcium can be obtained from heparin sodium by ion exchange. Heparin sodium has a strong negative charge of physical and chemical properties, can interfere with many aspects of the coagulation process, in vivo and in vitro have anticoagulation effect. It is mainly through binding with antithrombin III to enhance the inhibitory effect of the latter on activated coagulation factors II, IX, X, XI and XII. The consequences involve preventing platelet aggregation and destruction, and interfering with the formation of thromboactivase; Prevents prothrombin from becoming thrombin; It inhibits thrombin, which prevents fibrinogen from becoming fibrin. If the sulfuric acid group is hydrolyzed or neutralized by protamine with a strong positive charge, it immediately loses its anticoagulant activity. In addition, heparin sodium external use has anti-inflammatory, analgesic and other effects. The pharmacological effect of heparin calcium is similar to heparin sodium, but the effect of anticoagulant factor Ⅱa is slightly stronger, and the effect of anticoagulant factor Xa is weaker. Heparin calcium also has the pharmacological effects of regulating blood lipids, anti-inflammation, anti-complement, anti-allergy, immune regulation and so on.

Uses of Heparin sodium powder.

Heparin sodium is a mucopolysaccharide biochemical drug extracted from porcine intestinal mucosa with strong anticoagulant activity. Mclcan discovered the femoral mucopolysaccharide heparin in dog liver tissue while studying the mechanism of blood clotting. Brinkous et al. have proved that heparin has anticoagulant activity. After heparin was used as an anticoagulant for clinical application for the first time, heparin has received attention from all countries in the world. Heparin has a strong anticoagulant effect and is the first choice for preventing and treating thrombosis diseases such as deep vein thrombosis. But so far there is no product that can completely replace it, so it is still one of the most important anticoagulant and antithrombotic biochemical drugs. It is widely used in medicine, for the treatment of acute myocardial infarction and pathogenic hepatitis, and the combination of ribonucleic acid can increase the efficacy of hepatitis B, combined with chemotherapy, is conducive to preventing thrombosis, and has a certain role in lowering blood lipids and improving human immune function.

Preparation of Heparin sodium powder.

Product method of Bulk Heparin sodium powder.

The intestinal mucosa of pigs, sheep, cattle and other animals is extracted and refined