Pharmaceutical Intermediates raw Materials Powder Celecoxib

CAS:169590-42-5

MF:C17H14F3N3O2S

MW:381.37

EINECS:685-962-5

Specification​: 99% min Celecoxib Powder

Sample:Celecoxib Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Celecoxib Powder Usage and Synthesis.

Celecoxib is a new generation compound with a unique mechanism of action that specifically inhibits cyclooxygenase-2 (COX-2). Inflammatory stimulation induces COX-2 production, which leads to the synthesis and accumulation of inflammatory prostaglandins, especially prostaglandin E2, which causes inflammation, edema, and pain. The drug can inhibit the production of inflammatory prostaglandins by inhibiting COX-2, and achieve anti-inflammatory, analgesic and antipyretic effects.

Uses of Celecoxib.

Celecoxib powder is used to treat arthritis. It has anti-inflammatory and analgesic effects and relieves the symptoms and signs of osteoarthritis and rheumatoid arthritis.

Pharmacological action of Celecoxib.

Celecoxib has anti-inflammatory and analgesic effects of NSAIDs. Due to the characteristics of its chemical structure, this product can be combined with COX-2 and has a selective inhibition effect on COX-2. The phenyl group of celeoxib binds to the hydrophobic channel of COX-2, and the hydrophilic sulfa group forms hydrogen chains with the 513 arginine and 90 histidine in the "side pocket" of COX-2. In addition, this product is closely combined with arginine at the position of COX-2120, and plays a role in inhibiting the conversion of COX-2 to arachidonic acid into prostaglandins, which is harmful to human body. Due to the subtle difference in the structure of COX-1 and COX-2, this drug cannot enter the molecule of COX-1, nor can it inhibit the conversion of COX-1 to arachidonic acid into prostaglandins. Therefore, this product has good anti-inflammatory and analgesic effects, protect gastric mucosa, maintain renal blood flow, regulate platelet aggregation, and solve the digestive tract irritation of commonly used NSAIDs.