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Pharmaceutical Pleuromulin Raw material powder
Product Overview:
The discovery of truncated laterin drugs was in the 1970s, and in 1978 the first drug listed by the Swiss company Novartis - Tymycin, mainly used to treat diarrhea, pneumonia and other related diseases in pigs. Up to now, four drugs of truncated pleurin have been developed: tymycin, vonimulin, azamoline and ratapaline. Taimycin and warnemyline are relatively toxic, and they are only used as animal-specific drugs at present, and Taimycin is the most effective and most effective. Azamoline and Retapaline were later developed for human use, but azamoline was shelved due to water solubility and bioavailability issues, and Retapaline is currently used in human medicine only.
Pharmaceutical Pleuromulin Raw material powder Attributes
CAS:125-65-5
MF:C22H34O5
MW:378.5
EINECS:204-747-5
Specification: 99% min Pleuromulin powder
Sample:Pleuromulin powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical Pleuromulin Raw material powder Details
Pleuromulin Powder Usage and Synthesis.
Pleurin truncatus is a broad-spectrum diterpene antibiotic produced by Pleurus. It can inhibit the protein synthesis of bacteria, thus achieving the effect of inhibiting bacterial growth. It works in a different way than other types of antibiotics. In the mechanism of action. Truncated pleurotins mainly act on the ribosome level of bacterial cells, and inhibit the synthesis of bacterial proteins by inhibiting the activity of peptidyl transferase, so as to achieve a broad spectrum antibacterial effect. The main skeleton of truncated pleurotins is composed of three rings, and the basic structure of the group is eight membered rings. The carbonyl group on the five-membered ring and the hydroxyl group on C-11 are the necessary groups for activity, and most foreign studies are to chemically modify C-14, so as to greatly improve its antibacterial activity and bioavailability. Because C-14 of the truncated pleurin drugs contains free hydroxyl groups, it is not active; By modifying C-14, the derivatives with enhanced antibacterial activity against bacteria and mycoplasma can be obtained.
Uses of Pleuromulin.
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Pharmacological action of Pleuromulin.
Product Method of Bulk Pleuromulin Powder.
