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Sulfaguanidine Raw materials powder
Product Overview:
Sulfanilamide and sulfanidine were once commonly used varieties of sulfanilamide drugs, because of their greater toxicity, they are generally not used as the drug of choice, and now they and acetaminobenzene sulfonyl chloride are only used as intermediates in the production of sulfanilamide drugs. Sulfanidine, also known as sulfanidine, stop dysentery tablets, the earliest for intestinal infection of sulfanidine drug, sulfanidine molecular structure has a strong basic guanidine, large dissociation, fat solubility is small, although there is a certain amount of absorption from the intestine after internal administration, but not enough to achieve effective blood concentration, so it is not used for systemic infection
Sulfaguanidine Raw materials powder Attributes
CAS:57-67-0
MF:C7H10N4O2S
MW:214.24
EINECS:200-345-9
Specification: 99% min Sulfaguanidine powder
Sample:Sulfaguanidine powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Store at -20°C
Shelf Life: 2 Years
Test Method: HPLC
Sulfaguanidine Raw materials powder Details
Drug interaction of Sulfaguanidine powder.
1, at the same time, the application of urine alkalization drugs can enhance the solubility of this product in alkaline urine, and increase excretion.
2, sulfanidine can not be used with p-aminobenzoic acid, p-aminobenzoic acid can be taken up by bacteria instead of this product, and the two are antagonistic. It should not be used with para-benzoyl-containing local anesthetics such as procaine, tetracaine, etc.
3, for those who take estrogen contraceptives, the long-term application of sulfamidine can lead to a reduction in the reliability of contraception and increase the chance of menstrual bleeding.
4, photosensitive additive effect may occur when combined with photosensitive drugs.
5, the need for vitamin K increased in those treated with this product.
Uses of Sulfaguanidine.
The drug of choice for the treatment of leprosy is suitable for the treatment of all types of leprosy and can improve clinical symptoms. The general mucosal lesions improve faster, the skin lesions improve more slowly, neuropathy is slower, so the course of treatment is long, easy to produce drug resistance, not easy to cure, in addition, can also be used to treat dermatitis herpetiformis, lupus erythematosus, psoriasis, podiomycosis and malaria. The preparation is in tablet form. This sulfonamides drug is used for intestinal antibacterial infections, such as bacillary dysenteric enteritis, and can also be used to prevent infection before intestinal surgery. In the pharmaceutical industry, it is generally used as an important raw material for sulfadiazine drugs such as SM2 and SD. Sulfamidine is a lower form of the sulfanilamide family that inhibits bacteria. It is mainly used for the production of sulfadiazine, sulfadiazine and other advanced sulfonamides.
In vitro study of Sulfaguanidine.
1, can be made of sulfanilamide and guanidine nitrate in soda ash melting, reducing compression to produce sulfanilamidine finished product.
2, can be prepared by the reaction of acetylsulfanilamide chloride and guanidine nitrate in the presence of sodium hydroxide in a mixed solution of acetone and water.
3, using p-nitrobenzene sulfonyl chloride as raw material, through catalytic hydrogenation, p-aminobenzene sulfonyl chloride is generated, and then ammoniated to generate sulfanilamide, and then react with guanidine nitrate to prepare sulfanidine.
Product Methods of Bulk Sulfaguanidine powder.
