Decoquinate powder supplier:Pharmaceutical raw materials Powder

CAS:18507-89-6

MF:C24H35NO5

MW:417.54

EINECS:242-389-1

Specification: 99% min Decoquinate Powder

Sample:Decoquinate Powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Ausreson

MOQ:1KG 

Appearance:white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

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Decoquinate powder Usage and Synthesis.

Decoxyquinate plays a role in the asexual reproductive stage of coccidia, and after entering sporozoite cells, it prevents their development by interfering with DNA synthesis. It begins to play a role in the early life history of coccidia and effectively avoids intestinal damage caused by coccidia. The addition of feed does not affect the digestion of feed and the absorption of nutrients.

A Concerning and Unapproved Use: For Small Ruminants (Goats/Sheep)

• Target: The parasite Cryptosporidium parvum.

• The Problem: Cryptosporidium is a protozoan that causes severe, often fatal, diarrhea in young kids and lambs. It is notoriously difficult to treat because it is resistant to most common antibiotics and anticoccidial drugs.

• The Hope: Some studies and a great deal of anecdotal evidence suggest that decoquinate may be effective in preventing cryptosporidiosis if given to newborns very early in life, before exposure.

• The Major Caveats:

  • Not Approved: This is not an FDA-approved use.

  • Prevention, Not Cure: It appears to be most effective as a preventative, not a treatment for an active infection.

  • Dosage is Critical and Unstandardized: There is no universally agreed-upon dosage, and improper dosing is ineffective or could be harmful.

  • Requires Veterinary Guidance: Anyone considering this use must work directly with a veterinarian to formulate a proper protocol.

Uses of Decoquinate.

Quinoline coccidium drugs. As a feed additive to prevent coccidiosis in broilers, 27.2g of this product is added to 1t feed. The product has low toxicity, good tolerance and wide safety range. Metabolism is rapid, 3 days after stopping the drug, the residual drug concentration in each tissue is less than 1ppm.

What is decoquinate used for?

What are Coccidia?

Coccidia are microscopic, single-celled parasites (protozoa) that infect the intestinal tracts of animals. This infection, known as coccidiosis, is a major and economically significant disease in poultry, cattle, sheep, goats, and rabbits.

How Does Decoquinate Work

It works by targeting the early developmental stages of the coccidia parasite (specifically, the sporozoites and first-generation merozoites) within the host animal's intestinal cells. It disrupts the parasite's energy metabolism, effectively halting its growth and reproduction before it can cause severe damage.

Drug combination of Decoquinate.

In order to improve the anti-coccidia effect and reduce the generation of resistance, combination drugs can be taken. In the early stage of coccidiosis (the asexual breeding stage of coccidiosis), the combination of decoxyquinate + diczulide or toltrizulide, diglobulin + maduricin ammonium, diglobulin + cloxypyridine can play a synergistic role, enhance the killing effect, and reduce the dose of each drug by 1/2. In the whole stage of coccidiosis, the combination of dicoccidiol + sulfaquinoxaline sodium and dicoccidiol + sulfachlorpyrazine sodium can be used to inhibit and kill coccidiol in both asexual and sexual breeding stages.

Product Methods of Decoquinate.

The reaction of 3, 4-dihydroxynitrobenzene with bromodecane in DMF medium to produce 3-hydroxy-4-decyl nitrobenzene. Then, 3-ethoxy-4-decanoxyaniline was prepared by ethoxylation and reduction. Then, 3-ethoxy-4-decanoxy-aniline is condensed with diethyl ethoxymethylmalonate to obtain 3-ethoxy-4-decanoxy-anilinyl methyl-diethyl malonate, which is finally condensed by heat conduction M A to obtain the finished product.